Molecular Pharmacology
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Recent papers in Molecular Pharmacology
Human soluble epoxide hydrolase (hsEH) has been shown to play a role in regulating blood pressure and inflammation. HsEH consists of an N-terminal phosphatase and a C-terminal epoxide hydrolase domain. In the present study, we examined... more
The aim of the present study was to formulate and evaluate Metformin HCl microspheres to produce a drug delivery system with better pharmaceutical and therapeutic properties. Metformin HCl microspheres were prepared by using ethyl... more
Staphylococci are a major health threat because of increasing resistance to antibiotics. An alternative to antibiotic treatment is preventing virulence by inhibition of bacterial cell-to-cell communication using the quorum-sensing... more
A novel is ligand namely 5,5'-(6-(4-methoxyphenoxy)-1,3,5-triazine-2,4-diyl)bis (azanediyl)diquinolin-8-ol (PBDQ-6) has been prepared and characterized. This ligand was characterized by IR, 1H-NMR, and elemental analysis. Coordination... more
A simple, fast and accurate method has been developed for the estimation of benzene content in Lovastatin by Gas Chromatography. The analysis was carried out on Perkin Elmer Clarus 600 GC-HS Chromatograph. The column... more
A new simple, accurate, precise and reproducible Ion chromatography method has been developed for the estimation of Methane sulfonic acid in Busulfan injectable dosage. The method which is developed is also validated in complete... more
The purpose of this study was to evaluate the possibility of taste masking of Levocetirizine dihydrochloride (L-CTZ) by means of inclusion complexation and ion exchange resin. Initially an attempt was given to mask the bitter taste of the... more
Objective of the study was to find out the Resistogram of the urinary isolates against different commonly prescribed antimicrobials according to CLSI guidelines. Out of total 319 test samples, in 56 cases bacterial pathogens were... more
The objective of present study was to develop pharmaceutically elegant and stable enteric coated tablet formulation for highly unstable drug in acidic environment using pH dependent polymers. Omeprazole is a specific and non-competitive... more
Impurity profiling is the process of acquiring and evaluating data that establishes biological safety of an individual impurity. Impurity is considered as any other organic material, besides the drug substance, or ingredients, arise out... more
A straightforward, efficient and more sustainable solvent-free method has been developed for the synthesis of benzimidazole derivatives to achieve yields that were comparable to or better than, those in conventional media. It is... more
An accurate, precise, simple and economical High Performance Liquid Chromatographic method for the Estimation of Bortezomib in its lyophilized dosage form has been developed. The method developed is Reverse Phase High Performance Liquid... more
Quality by Design (QbD) refers to a holistic approach towards drug development. The purpose of research was to implement quality by design to study prospective process validation of 4 mg Salbutamol Sulphate Tablets with risk-based... more
Herbal drugs are traditional method of treating the disease in the world wide, the plant having ability to treat the disease is known as medicinal plants. Several types of medicinal plants are exists in the nature and effective in... more
Ziziphus oenoplia Linn., Mill, is a commonly occurring thorny shrub found to have many uses such as anthelmintic, antiseptic, hepatoprotective, stomachalgia, digestive etc. It is also used in ascaris infection and healing of wounds. The... more
Phenylhydrazine (PHZ), a potent chemical causes toxicity on various tissues at various levels. Administration of phenylhydrazine mainly causes haematotoxicity which leads to the haemolytic anemia. In mammals PHZ induced anemia increased... more
Aceclofenac is non-steroidal anti-inflammatory drug with marked anti-inflammatory and analgesic properties. It is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.... more
This paper reviews constructed drug delivery systems applying osmotic principles for controlled drug release from the formulation. Osmotic devices which are tablets coated with walls of controlled porosity are the most promising strategy... more
The present study was designed to analyze the various phytoconstituents present in different extracts of seeds of Calotropis gigantea. Extracts of seeds of C. gigantea were prepared in different solvents viz. methanol, chloroform,... more
Objective structured practical examination (OSPE) a new assessment tool has been implemented in a few medical colleges. This method of assessment was planned to be implemented in our medical college, before which the authors planned to... more
Process analytical technology (PAT) involves the use of different technologies and tools to build quality into the products. Effective PAT implementation comprise of science-based understanding of the physical, chemical and mechanical... more
Multiple emulsions are also known as emulsions of emulsions, liquid membrane system or double emulsion. Multiple emulsions are polydispersed systems where both oil in water & water in oil emulsions exist simultaneously. This review... more
The objective of this article is to review the principles underlying the development and evaluation of mucoadhesive microspheres and the research work carried out on these systems. Mucoadhesion is a topic of current interest in the design... more
The aim of the present work to evaluate the anticataract activity of aqueous extract of Asparagus racemosus root using in vitro model of goat lens. In the in vitro study, goat lenses were incubated in artificial aqueous humor containing... more
Peptic ulcer represents a serious medical condition, Approximately 500,000 new cases are reported each year, with 5 million people alone affected in United States alone. The highest risks of contracting peptic ulcer disease are those... more
Q- Analysis method for simultaneous estimation of Metformin HCl and Gliclazide in tablet dosage form have been developed. The method was simple, precise, accurate, reproducible and economical. Linearity was observed in the concentration... more
In the present study, the potential of liquisolid systems to improve the dissolution properties of poorly water soluble agents was investigated using Aceclofenac. Aceclofenac is a Non steroidal anti-inflammatory drug used orally for... more
Oral route having the high patient compliance in regarded as the most convenient, safest and also the most economical method of drug delivery. Fast dissolving tablets are one such most advantageous example of the oral drug delivery. These... more
Use of the members of the genus Allium L. in Northeast India is quite significant from the perspective of ethnopharmacology. The pharmacological aspect of the genus Allium L. have been clinically evaluated since long due to... more
Euphorbia neriifolia Linn. (Euphorbiaceae) is traditionally used to treat diabetes mellitus. The extract of Euphorbia neriifolia Linn. are having potential in the development of drug for diabetes due to their antidiabetic activity.... more