Pharmacology

Recent articles

Research ArticleJanuary 12, 2023
Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models
- Maaya Morita,
- Aki Yoneda,
- Nagisa Tokunoh,
- Tatsumi Masaki,
- Keisuke Shirakura,
- Mayumi Kinoshita,
- Rina Hashimoto,
- Naoya Shigesada,
- Junya Takahashi,
- Masashi Tachibana,
- Shota Tanaka,
- Masanori Obana,
- Nobumasa Hino,
- Masahito Ikawa,
- Kazutake Tsujikawa,
- Chikako Ono,
- Yoshiharu Matsuura,
- Hiroyasu Kidoya,
- Nobuyuki Takakura,
- Yoshiaki Kubota,
- Takefumi Doi,
- Kazuo Takayama,
- Yasuo Yoshioka,
- Yasushi Fujio,
- Yoshiaki Okada,
This is an addendum toComplex viscosity of helical and doubly helical polymeric liquids from general rigid bead-rod theory
Research ArticleDecember 27, 2022
Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity
- Claudia M. Rohr,
- Daniel J. Sprague,
- Sang-Kyu Park,
- Nicholas J. Malcolm,
- Jonathan S. Marchant and
This is an addendum toComplex viscosity of helical and doubly helical polymeric liquids from general rigid bead-rod theory
December 9, 2022view on pnas nexus
Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening
This is an addendum toComplex viscosity of helical and doubly helical polymeric liquids from general rigid bead-rod theory
Research ArticleDecember 6, 2022
Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice
- Tadatoshi Sato,
- Christian D. Castro Andrade,
- Sung-Hee Yoon,
- Yingshe Zhao,
- William J. Greenlee,
- Patricia C. Weber,
- Usha Viswanathan,
- John Kulp,
- Daniel J. Brooks,
- Marie B. Demay,
- Mary L. Bouxsein,
- Bruce Mitlak,
- Beate Lanske,
- Marc N. Wein,
This is an addendum toComplex viscosity of helical and doubly helical polymeric liquids from general rigid bead-rod theory
Research ArticleDecember 5, 2022
A structural mechanism of nuclear receptor biased agonism
This is an addendum toComplex viscosity of helical and doubly helical polymeric liquids from general rigid bead-rod theory
Research ArticleNovember 30, 2022
High-throughput functional annotation of natural products by integrated activity profiling
- Suzie K. Hight,
- Trevor N. Clark,
- Kenji L. Kurita,
- Elizabeth A. McMillan,
- Walter Bray,
- Anam F. Shaikh,
- Aswad Khadilkar,
- F. P. Jake Haeckl,
- Fausto Carnevale-Neto,
- Scott La,
- Akshar Lohith,
- Rachel M. Vaden,
- Jeon Lee,
- Shuguang Wei,
- R. Scott Lokey,
- Michael A. White,
- Roger G. Linington,
- John B. MacMillan,
This is an addendum toComplex viscosity of helical and doubly helical polymeric liquids from general rigid bead-rod theory
Research ArticleNovember 30, 2022
Inflammatory response to retrotransposons drives tumor drug resistance that can be prevented by reverse transcriptase inhibitors
This is an addendum toComplex viscosity of helical and doubly helical polymeric liquids from general rigid bead-rod theory
Research ArticleNovember 21, 2022
A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G₄C₂)^exp in c9ALS/FTD via the nuclear RNA exosome
- Jessica A. Bush,
- Samantha M. Meyer,
- Rita Fuerst,
- Yuquan Tong,
- Yue Li,
- Raphael I. Benhamou,
- Haruo Aikawa,
- Patrick R. A. Zanon,
- Quentin M. R. Gibaut,
- Alicia J. Angelbello,
- Tania F. Gendron,
- Yong-Jie Zhang,
- Leonard Petrucelli,
- Torben Heick Jensen,
- Jessica L. Childs-Disney,
- Matthew D. Disney,
This is an addendum toComplex viscosity of helical and doubly helical polymeric liquids from general rigid bead-rod theory
Research ArticleNovember 21, 2022
Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo
- Shi Liu,
- Zhen Yu,
- Eileen J. Daley,
- Craig A. Bingman,
- Austin T. Bruchs,
- Thomas J. Gardella,
- Samuel H. Gellman,
This is an addendum toComplex viscosity of helical and doubly helical polymeric liquids from general rigid bead-rod theory
Research ArticleNovember 7, 2022
Genetically-encoded BRET probes shed light on ligand bias–induced variable ion selectivity in TRPV1 and P2X5/7
This is an addendum toComplex viscosity of helical and doubly helical polymeric liquids from general rigid bead-rod theory

Susan G. Amara
National Institutes of Health
Francisco Bezanilla
The University of Chicago
Nancy Carrasco
Vanderbilt University
Mark T. Nelson
University of Vermont
Donald W. Pfaff
The Rockefeller University
Nieng Yan
Princeton University

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Pharmacology

Recent articles

Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models

Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity

Pharmacological potentiators of the calcium signaling cascade identified by high-throughput screening

Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice

A structural mechanism of nuclear receptor biased agonism

High-throughput functional annotation of natural products by integrated activity profiling

Inflammatory response to retrotransposons drives tumor drug resistance that can be prevented by reverse transcriptase inhibitors

A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G₄C₂)^exp in c9ALS/FTD via the nuclear RNA exosome

Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo

Genetically-encoded BRET probes shed light on ligand bias–induced variable ion selectivity in TRPV1 and P2X5/7

Editors

Susan G. Amara

Francisco Bezanilla

Nancy Carrasco

Mark T. Nelson

Donald W. Pfaff

Nieng Yan

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Further Reading

Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei

On the activation of soluble guanylyl cyclase by nitric oxide

Decreased intracellular calcium mediates the histamine H₃-receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings

Effective connectivity changes in LSD-induced altered states of consciousness in humans

A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G₄C₂)^exp in c9ALS/FTD via the nuclear RNA exosome

Deep learning identifies synergistic drug combinations for treating COVID-19

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor

Target identification using drug affinity responsive target stability (DARTS)

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