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Rickets is seen in association with vitamin D deficiency and in several genetic disorders
associated with abnormal mineral ion homeostasis. Studies in vitamin D receptor (VDR)-null
mice have demonstrated that expansion of the late hypertrophic chondrocyte ...
The major physiological role of the vitamin D receptor (VDR) is the maintenance of
mineral ion homeostasis. Mutation of the VDR, in humans and mice, results in alopecia.
Unlike the effects of the VDR on mineral ion homeostasis, the actions of the VDR that
...
We have previously shown that the retinoblastoma protein (pRb) can activate expression
of Runx2-dependent, bone-specific genes in cultured cells. We now show that pRb also
plays a role early in osteogenesis, and that in primary RB1−/− calvarial cells ...
Osteoporosis is a major public health problem. Currently, there are no orally available
therapies that increase bone formation. Intermittent parathyroid hormone (PTH) stimulates
bone formation through a signal transduction pathway that involves inhibition ...
Vitamin D, the major steroid hormone that controls mineral ion homeostasis, exerts
its actions through the vitamin D receptor (VDR). The VDR is expressed in many tissues,
including several tissues not thought to play a role in mineral metabolism. ...