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Table 1: Mouse CD Cellular Antigens
Mouse CD Cellular Antigens
|
Antigen Name |
Other Names |
MW |
Structure |
Distribution |
Function |
eBioscience Clone |
CD1d
|
CD1.1/1.2, Ly-38
|
43-49kD
|
IgSF
|
leukocytes, intestinal epith
|
Ag presentation, mucosal
immunity, w/ β2m, ligand
for NKT cells
|
1B1
|
CD2
|
LFA-2, Ly-37, SRBC-R
|
45-58kD
|
IgSF
|
thymocytes, T, NK, B,
pre-B, myeloid, erythrocytes
|
adhesion, T activation, CD48 receptor
|
RM2-5
|
CD3d
|
T3d
|
20kD
|
IgSF
|
T, thymocyte subset, NKT
|
TCR subunit, TCR expression & signaling
|
|
CD3e
|
T3e
|
20kD
|
IgSF
|
T, thymocyte subset, NKT
|
TCR subunit, TCR expression & signaling
|
145-2C11
|
|
|
|
|
|
|
17A2
|
|
|
|
|
|
|
500A2
|
CD3g
|
T3g
|
25kD
|
IgSF
|
T, thymocyte subset, NKT
|
TCR subunit, TCR expression & signaling
|
|
CD4
|
Ly-4, L3T4
|
55kD
|
IgSF
|
thymocyte subset, T subset, DC
|
TCR coreceptor, thymic differentiation, T activation,
MHC class II receptor
|
GK1.5
|
|
|
|
|
|
|
RM4-5
|
|
|
|
|
|
|
RM4-4
|
CD5
|
Ly-1
|
67kD
|
SRCRSF
|
thymocytes, T, B subset (B1)
|
T activation, T-B interaction, CD72 receptor
|
53-7.3
|
CD6
|
T12
|
100-130kD
|
SRCRSF
|
thymocytes, T, neurons, not on B
|
T differentiation & costimulation, CD166 receptor
|
|
CD7
|
|
40kD
|
IgSF
|
human early T marker, CD7KO has normal phenotype
|
|
|
CD8a
|
Ly-2
|
32-34kD
|
IgSF
|
thymocyte subset, T subset , DC subset, not fresh NK
|
TCR coreceptor, MHC class I receptor,
T differentiation, homodimer or heterodimer w/ CD8b
|
53-6.7
|
CD8b
|
Ly-3
|
30kD
|
IgSF
|
thymocyte subset, T subset, not fresh NK
|
TCR coreceptor, MHC class I receptor,
T differentiation, heterodimer w/ CD8a
|
CT-CD8b
|
|
|
|
|
|
|
eBioH35-17.2 (H35-17.2)
|
CD9
|
p24
|
24-27kD
|
TM4SF
|
myeloid, platelets, Tact, B subset
|
cell adhesion, migration, T costimulation
|
eBioKMC8
|
CD10
|
CALLA, NEP, Mme
|
100kD
|
type II TM
|
B precursors, fibroblasts,
BM stromal cells
|
zinc-binding metalloproteinase,
neutral endopeptidase
ectoenzyme, B development
|
eBioR103
|
CD11a
|
integrin αL, Ly-15, Itgal
|
80kD
|
IntgF
|
T, B, NK, gran, mono,
mac, DC, thymocytes
|
CD11a/CD18 (LFA-1)
receptor for ICAM-1
and ICAM-2,
intercellular adhesion,
T costimulation
|
M17/4
|
CD11b
|
Mac-1, integrin αM,
Itgam, CR3
|
170kD
|
IntgF
|
myeloid, NK, Tact, B subset
|
CD11b/CD18 receptor for
CD54 and CD102, adhesion
to ECM, fibrinogen,
& complement iC3b
|
M1/70
|
CD11c
|
p150, integrin αX, Itgax, CR4
|
150kD
|
IntgF
|
DC, myeloid, NK, T subset
|
CD11c/CD18 receptor for fibrinogen & iC3b, adhesion
|
N418
|
CD13
|
Aminopeptidase N, Lap1
|
150kD
|
Type II TM
|
myeloid, endoth, DC
|
zinc-binding metalloproteinase, antigen processing
|
mAb (please inquire)
|
CD14
|
LPS-R, Mo2
|
53-55kD
|
GPI-linked
|
mac, granlow
|
receptor for LPS/LBP, LPS recognition
|
Sa2-8
|
CD15
|
Lewis-X
|
|
CHO
|
transient in brain
|
fucosyl transferase (Fut4)
|
|
CD16
|
FcγRIII, Ly-17, Fcgr3
|
50-60kD
|
IgSF
|
NK, neutrophils, mast cells, mac
|
Fcγ low affinity receptor, phagocytosis, ADCC,
NK activation
|
93
|
CD18
|
Integrin β2, Itgb2
|
90-95kD
|
IntgF
|
leukocytes
|
w/ CD11a, b and c, adhesion
|
M18/2
|
CD19
|
B4
|
95kD
|
IgSF
|
B, FDC, good B lineage marker, not plasma cells
|
w/ CD21 & CD81, BCR coreceptor,
B activation/differentiation
|
MB19-1
|
|
|
|
|
|
|
6D5
|
|
|
|
|
|
|
eBio1D3 (1D3)
|
CD20
|
Ly-44, B1, Ms4a2
|
33-37kD
|
TM4SF
|
B, T subset
|
B differentiation/activation
|
AISB12
|
CD21
|
CR2, CR1
|
150kD
|
CCRSF
|
B, DC
|
CD21/CD35 other variants of CR2 gene, complement
C3d receptor, w/ CD19 & CD81, BCR coreceptor
|
eBio4E3
|
|
|
|
|
|
|
eBio8D9 (8D9)
|
CD22
|
Lyb-8, Siglec-2
|
140-160kD
|
IgSF/sialoadhesins
|
B
|
adhesion, B-mono & B-T interactions, B activation, BM homing receptor for IgD+ B cells, CD75 counter-receptor
|
2D6
|
CD23
|
FcεRII, Ly-42, Fcer1a
|
45-49kD
|
C-type lectin
|
B, mono, mac, gran, platelets, FDC, not B1 cells
|
CD19/CD21/CD81 receptor, low affinity IgER,
signaling
|
B3B4
|
CD24a
|
HSA, Ly-52, Nectadrin
|
35-52kD
|
GPI-linked
|
B, gran, mono, mac, Tact, erythrocytes, neurons
|
several isoforms, B differentiation & proliferation,
adhesion, T costimulation, CD62P receptor
|
30-F1
|
|
|
|
|
|
|
M1/69
|
CD25
|
Ly-43, p55, IL2Rα
|
55kD
|
Type I TM
|
pre-B, pre-T, Tact, Bact, DC subset, mono, mac
|
low affinity IL-2 binding, w/ IL-2Rβ & γ forms IL-2 receptor high affinity, also soluble form
|
PC61.5
|
|
|
|
|
|
|
eBio3C7
|
|
|
|
|
|
|
eBio7D4
|
CD26
|
DPP4, THAM
|
110kD
|
Type II TM
|
thymocyte subset, Tact, B, NK, epith
|
dipeptidyl peptidase ectoenzyme, activation, adhesion
|
mAb (please inquire)
|
CD27
|
T14, Tnfrsf7
|
45kD
|
TNFRSF
|
medullary thymocytes, T, NK, B subset
|
CD70 receptor, T costimulation
|
LG.7F9
|
CD28
|
Tp44
|
45kD
|
IgSF
|
T, thymocytes, NK
|
CD80 (B7-1) & B7-2 (CD86) receptor, T costimulation
|
37.51
|
CD29
|
Integrin β1, gpIIa, Itgb1
|
130kD
|
IntgF
|
leukocytes, fibroblasts, endoth, epith
|
w/ CD49a-f (VLA-1-6), w/ CD51(αvβ1), CD29/CD49a
( VLA-1) receptor for VCAM-1, MAdCAM-1 & ECM,
VLAb, adhesion, embryonic development
|
eBioHMb1-1
|
|
|
|
|
|
|
eBioKMI6
|
CD30
|
Ki-1, Tnfrsf8
|
105-120kD
|
TNFRSF
|
Bact, Tact
|
CD153 receptor, lymphocyte proliferation, apoptosis,
peripheral tolerance
|
mCD30.1
|
CD31
|
PECAM-1, pgIIa
|
130-140kD
|
IgSF
|
platelets, gran, endoth, DC, mono subset, T subset,
B subset, LAK
|
multiple isoforms, CD38 receptor, signaling,
platelet-endoth adhesion
|
390
|
CD32
|
FcγRII,
Ly-17, Fcgr2b
|
40-60kD
|
IgSF
|
mono, mac, gran, B, Tact, not NK
|
low affinity Fc receptor for
aggregated Ig/immune
complexes, ADCC
|
93
|
CD33
|
Siglec-3, gp67
|
67kD
|
IgSF, sialoadhesins
|
myeloid progenitors;
gran
|
possible role in
hematopoiesis, binds
sialic-acid
|
|
CD34
|
Mucosialin
|
90-120kD
|
Sialomucin family
|
hematopoietic precursors,
capillary endoth, BM stroma,
mast cells
|
CD62L receptor, adhesion
|
RAM34
|
CD35
|
Cr1, Cr2
|
190kD
|
SRCRSF
|
B, granact, FDC
|
CD21 & CD35 alternative splice variants of Cr2 gene,
binds C3b & C4b, adhesion, phagocytosis
|
eBio4E3
|
|
|
|
|
|
|
eBio8D9 (8D9)
|
CD36
|
FAT, fatty acid translocase
|
88kD
|
|
platelets, adipocytes, mono, mac, endoth, erythrocyte
|
oxidized LDL receptor
|
No. 72-1
|
CD37
|
|
|
TM4SF
|
mRNA: lymphoid, myeloid
|
T-B interaction
|
|
CD38
|
Cd38-rs1, T10
|
42kD
|
Type II TM
|
B, marginal zone B (high), Tact, thymocyte subset,
subsets in yolk sac, in fetal liver, in BM
|
B activation, CD31 receptor, ectoenzyme,
ADP-ribosyl cyclase/hydrolase
|
90
|
CD39
|
Entpd1
|
70-100kD
|
|
lymphocyteact, microglia, endoth
|
ecto-nucleoside trisphosphate diphosphohydrolase
|
24DMS1
|
CD40
|
gp39 receptor, Tnfrsf5
|
45-50kD
|
TNFRSF
|
B, mono, mac, T subset, DC, endoth, thymic epith,
induced on cardiac myocytes
|
CD154 receptor, T-B interaction, B costimulation and
survival, isotype-switching
|
1C10
|
|
|
|
|
|
|
HM40-3
|
CD41
|
gpIIb, Itga2b, CD41b
|
110-125kD
|
IntgF
|
platelets, megakaryocytes
|
w/ CD61 forms GPIIb/IIIa, binds fibrinogen,
fibronectin, vWF & thrombospondin,
platelet activation, aggregation
|
eBioMWReg30
|
CD42
|
Gp9, GPIX
|
20kD
|
LRRF
|
platelets, megakaryocytes
|
platelet activation, aggregation
|
|
CD43
|
Leukosialin, Ly-48, Spn, sialophorin
|
115 & 135kD
|
Type I TM
|
T, Tact, early B, B subset, plateletslow, not resting B,
not DC
|
isoforms, signaling, CD54R, B survival, adhesion
|
eBioR2/60
|
CD44
|
Pgp-1, Ly-24, HERMES
|
80-95 & 130kD
|
|
broad, memory T, not platelets,
or hepatocytes
|
binds hyaluronic acid,
leukocyte adhesion/homing,
T activation, tumor metastasis
|
IM7
|
|
|
|
|
|
|
eBioKM114
|
CD44R
|
variants of CD44
|
|
|
restricted & varied
|
adhesion, metastasis,
receptor for Hyaluronate
|
|
CD45
|
LCA, Ly-5, Ptprc
|
180-240kD
|
PTPR family,
ASV
|
leukocytes, not mature
erythrocytes
|
tyrosine phosphatase, leukocyte differentiation/activation, pan-leukocyte marker
|
30-F11
|
CD45.1
|
|
|
|
Ly-5.2 strains: SJL, DA, STS/A, RIII
|
|
A20
|
CD45.2
|
|
|
|
Ly-5.1 strains: BALB/c, C3H, C57BL/6, DBA/1, DBA/2,
AKR, A, 129
|
|
104
|
CD45R/CT1
|
|
|
CT1 CHO
|
cytotoxic Tact
|
|
|
CD45R
|
B220
|
220kD
|
|
B, NK progenitors, LAK, Tact
|
|
RA3-6B2
|
CD45RA
|
|
|
exon A isoform
|
|
|
|
CD45RB
|
|
200-240kD
|
exon B isoform
|
T subset, B, mono, mac
|
|
C363.16A
|
CD45RC
|
|
200-240kD
|
exon C isoform
|
T subset, B
|
|
GL24
|
CD45RO
|
|
180kD
|
isoform not exons A, B, or C
|
Tact, Bact, DC subset
|
|
|
CD46
|
MCP, membrane cofactor protein
|
|
CRRSF
|
broad
|
complement regulation, role in fertilization
|
|
CD47
|
IAP, Itgp
|
50kD
|
IgSF
|
hematopoietic cells, epith, endoth,
fibroblasts, platelets
|
w/ β3 integrins, leukocyte adhesion, migration, activation, extravasation of PMN, binds SIRPα
|
miap301
|
CD48
|
Blast-1, BCM-1, Sgp-60
|
45kD
|
IgSF, GPI-linked
|
broad on lymphocytes, not fibroblasts
|
adhesion, T costimulation, CD2 and Ly-9 receptor
|
HM48-1
|
CD49a
|
VLA-1, Integrin α1, Itga1
|
180kD
|
IntgF
|
Tact, endoth
|
adhesion, CD49a/CD29 binds collagen & laminin
|
|
CD49b
|
VLA-2, Integrin α2, Itga2
|
165kD
|
IntgF
|
platelets, T subset, megakaryocytes, NK subset
|
adhesion, CD49b/CD29 binds collagen & laminin
|
HMa2
|
|
|
|
|
|
|
DX5
|
CD49c
|
VLA-3, Integrin α3,
Itga3
|
125kD
|
IntgF
|
B subset, Tlow
|
CD49c/CD29 binds laminin, fibronectin, collagen
|
|
CD49d
|
VLA-4, Integrin α4, Itga4
|
150kD
|
IntgF
|
T, B, mono
|
CD49d/CD29 binds fibronectin,
VCAM-1, w/ β7 forms
LPAM-1 & binds to
MAdCAM-1,
homing receptor
|
R1-2
|
CD49e
|
VLA-5,
Integrin α5, Itga5
|
135kD
|
IntgF
|
thymocytes, Tact
|
adhesion, CD49e/CD29
binds fibronectin
|
eBioHMa5-1
|
CD49f
|
VLA-6, Integrin α6, Itga6
|
120kD
|
IntgF
|
memory T, thymocytes, platelets
|
adhesion, CD49f/CD29 binds laminin
|
eBioGoH3
|
CD50
|
Icam5, Ticn, Telencephalin
|
130kD
|
IgSF
|
memory T, thymocytes, platelets
|
adhesion, CD49f/CD29 binds laminin
|
|
CD51
|
VitronectinR, Integrin αv, Itgav
|
125, 24kD
|
IntgF
|
platelets, megakaryocytes, endoth, osteoblasts,
melanoma
|
adhesion, CD51/CD61 binds vitronectin,
von Willebrand factor, fibrinogen & thrombospondin
|
RMV-7
|
CD52
|
CAMPATH-1, MB7, CLS1
|
12kD
|
GPI-linked
|
mature lymphocytes
|
|
|
CD53
|
OX-44
|
35-42kD
|
TM4SF
|
leukocytes, DC, osteoblasts, osteoclasts
|
signaling
|
|
CD54
|
ICAM-1, Ly-47
|
85-110kD
|
IgSF
|
endoth, mono, resting lymph (high on activation)
|
CD11a/CD18(LFA-1), CD11b/CD18(Mac-1) &
CD43 receptor, adhesion, T costimulation
|
YN1/1.7.4
|
|
|
|
|
|
|
eBioKAT-1 (KAT-1, KAT1)
|
CD55
|
Decay Accelerating Factor
|
60-70kD
|
CCRSF
|
broad, induced in uterus by estrogen
|
similar to Crry, protection from autologous
complement attack
|
|
CD56
|
NCAM
|
20-185kD
|
IgSF
|
neural tissue, multiple isoforms
|
adhesion, neuron development, skeletal myogenesis
|
|
CD57
|
|
|
B3GAT1
|
GlucuronsyltransferaseP
|
|
|
CD58(H)
|
LFA-3
|
|
|
not defined in mouse
|
|
|
CD59
|
Protectin, MAC-inhibitor
|
19kD
|
GPI-linked
|
broad
|
binds complement C8 & C9, blocks membrane attack
complex assembly
|
|
CD60(H)
|
|
|
CHO
|
not defined in mouse
|
|
|
CD61
|
GPIIIa, Integrin β3, Itgb3
|
105kD
|
IntgF
|
platelets, megakaryocytes, mac, endoth
|
CD41/CD61 or CD51/CD61 complexes adhere to
ECM
|
2C9.G3
|
CD62E
|
E-selectin, ELAM-1, Sele 97
|
107-115kD
|
Selectin
|
endoth
|
sialyl-Lewis x receptor, leukocyte rolling & migration,
tumor metastasis
|
|
CD62L
|
L-selectin, LECAM-1, sell
|
74 & 95kD
|
Selectin
|
B, T, mono, gran, NK, thymocytes
|
CD34, GlyCAM, & MAdCAM-1 receptor,
lymphocyte homing, leukocyte tethering & rolling
|
MEL-14
|
CD62P
|
P-selectin, Selp
|
140kD
|
Selectin
|
plateletsact, endoth
|
CD162 & sialyl LewisX receptor, adhesion,
neutrophil rolling, platelet-neutrophil &
platelet-mono interactions, binds to CD24
|
|
CD63
|
MLA1
|
53kD
|
TM4SF
|
plateletsact, mono, mac
|
activated platelets marker, lysosomal membrane
protein, translocates to surface upon activation,
melanoma associated antigen
|
|
CD64
|
FcγRI
|
72kD
|
IgSF
|
mono, mac, DC, granact
|
high affinity IgG receptor, phagocytosis,
trypsin-sensitive, ADCC
|
|
CD65(H)
|
|
|
|
not defined in mouse
|
|
|
CD66a
|
Ceacam1, C-Cam
|
|
IgSF, CEA family
|
colon, liver, hematopoietic tissues
|
cell-cell interaction, hepatitis virus receptor
|
CC1
|
CD68
|
Macrosialin, gp110
|
87-115kD
|
Sialomucin
|
predominantly intracellular, tissue mac, DClow
|
lysosomal associated protein
|
|
CD69
|
Activation Inducer Molecule, VEA
|
35-39kD
|
C-type lectin
|
Tact, Bact, NKact, granact, thymocytes, platelets
|
activation, early activation marker
|
H1.2F3
|
CD70
|
Ki-24, Tnfsf7
|
50, 70, 90, 160kD
|
TNFSF
|
Bact, Tact, cardiac myocytes
|
CD27 receptor, T & B costimulation
|
FR70
|
CD71
|
T9, Trfr
|
95kD
|
Type II TM, dimer
|
proliferating cells, reticulocytes, erythroid precursors
|
transferrin receptor, iron uptake, cell activation
|
R17217
|
CD72
|
Lyb-2
|
40-45kD
|
C-type lectin, homodimer
|
B, FDC, T subset, polymorphic extracellular portion
|
CD5 & CD100 receptor, B costimulation
|
|
CD73
|
Nt5e
|
69kD
|
GPI-linked
|
|
ecto-5-nucleotidase, T costimulation, adhesion
|
eBioTY/11.8
|
CD74
|
Ii, Ia-invariant chain
|
33-43kD
|
Type II TM
|
B, mac, mono
|
MHC class II traffic & function, antigen presentation
|
mAb (please inquire)
|
CD75
|
|
|
|
BM homing of recirculating B cells, CD22 counter-receptor
|
|
|
CD77(H)
|
|
|
|
not defined in mouse
|
|
|
CD79a
|
Iga, mb-1, Ly-54
|
33 & 45kD
|
IgSF
|
B
|
BCR subunit, BCR expression & signaling
|
|
CD79b
|
Igb, B29
|
37kD
|
IgSF
|
B
|
BCR subunit, BCR expression & signaling
|
|
CD80
|
B7, B7-1, Ly-53
|
60kD
|
IgSF
|
Bact, Tact, mono, mac, DC, pancreatic β cells
|
CD28 & CD152 receptor, costimulation, T-B interaction
|
16-10A1
|
CD81
|
TAPA-1
|
26kD
|
TM4SF
|
T, B, NK, thymocytes, DC, endoth, fibroblast,
neuroblastomas, melanomas
|
w/ CD19 & CD21, signaling, T costimulation
|
Eat-2
|
CD82
|
KAI1, C33
|
50-53kD
|
TM4SF, ASV
|
Tact, mRNA: spleen, kidney
|
inhibits tumor cell mobility
|
|
CD83
|
|
43kD
|
IgSF, Siglec family
|
DC, Tact, mRNA: spleen & brain
|
regulation of T response, binds to a
ligand on B cells
|
Michel17
|
CDw84
|
|
|
IgSF
|
B, mac, mRNA: hematopoietic tissue
|
|
|
CD85
|
|
|
|
MHC class I recognition
|
|
|
CD86
|
B70, B7-2, Ly-58
|
80kD
|
IgSF
|
mono, Bact, Tact, DC
|
CD28/CD152 receptor,
T costimulation,
T-B interaction
|
PO3.1
|
|
|
|
|
|
|
GL1
|
CD87
|
UPA-R, Plaur
|
|
GPI-linked
|
|
mRNA: muPAR1 luminal epith of
gastric mucosa, muPAR2 basal epith,
PAR2 secreted uPA binding protein
|
|
CD88
|
C5aR, C5r1
|
40kD
|
TM7SF
|
gran, neurons, astrocytes, microglia
|
C5a receptor, granulocyte activation,
neurodegeneration
|
|
CD89
|
FcαR, IgA receptor
|
55-75kD
|
IgSF
|
mono, mac, neutrophils, B subset, T subset
|
phagocytosis, degranulation, respiratory burst
|
|
CD90
|
Thy-1
|
18kD
|
IgSF, GPI-linked
|
thymocytes, T, hematopoietic subset, neurons, not B
|
hematopoietic stem cell & neuron differentiation,
T activation
|
G7
|
CD90.1
|
|
|
|
thy1a(thy1.1) strains: AKR & RF
|
|
HIS51
|
CD90.2
|
|
|
|
thy1b(thy1.2) all other strains
|
|
53-2.1
|
|
|
|
|
|
|
30-H12
|
CD91
|
lrp1,
A2mr
|
600kD
|
LDL receptor
family
|
mono, mac,
neurons, liver,
fibroblasts
|
receptor
for a-2-
macroglobulin,
LDL, HSPgp96,
apolipoprotein,
lipoprotein
metabolism
|
|
CDw92(H)
|
|
|
|
not defined in mouse
|
|
|
CDw93
|
AA4.1 antigen, C1qRp, early B lineage marker, Ly68
|
130-140kD
|
C-type lectin
|
hematopoietic progenitor marker for early B cells, endo, megakaryoblasts, platelets
|
phagocytic complement C1q receptor
|
AA4.1
|
CD94
|
KP43, klrd1
|
43kD
|
C-type lectin
|
NK, T subset
|
w/ NKG2, inhibits NK function
|
18d3
|
CD95
|
Apo-1, Fas
|
35kD
|
TNFRSF
|
thymocytes, lymphocytesact
|
CD95L(CD178) receptor, apoptosis induction, immune
system regulation, lpr mutation
|
15A7
|
CD96
|
TACTILE, T cell ACTivation Increased Late
Expression
|
160kD
|
IgSF
|
mRNA: spleen, mammary gland
|
adhesion of activated T & NK
|
|
CD97
|
TM7LN1 TM7S
|
|
|
lymphoid, myeloid
|
CD55 receptor
|
|
CD98
|
4F2, Ly-10
|
80, 40kD
|
|
thymocytes, lymphocytes, mono, BM
|
cell activation, calcium flux
|
RL388
|
CD99
|
Pilr-1, D4
|
|
|
|
|
|
CD100
|
Sema4d, semaphorinH
|
150kD
|
IgSF
|
mRNA: lymphoid & nervous tissues
|
CD72 receptor, role in immune & nervous systems
|
BMA-12
|
CD101
|
IgSF3
|
|
IgSF
|
|
role in susceptibility to type I diabetes
|
Moushi101
|
CD102
|
ICAM-2, Ly-60
|
55-65kD
|
IgSF
|
lymphocytes, mono, platelets, endoth
|
binds CD11a/CD18 (LFA-1), costimulation
|
|
CD103
|
HML-1, αIEL, αE integrin, Itgae
|
150kD
|
IntgF
|
intraepithelial lymphocytes, BM mast, lymphocytesact
|
w/ integrin β7, binds E-cadherin, lymphocyte homing
|
2E7
|
CD104
|
β4 integrin, Itgb4
|
220kD
|
IntgF
|
epith, endoth, immature thymocytes,
Schwann cells, tumor cells, keratinocytes
|
w/ CD49f, cell adhesion/migration, differentiation,
tumor metastasis, a6b4 is tumor associated
Ag Tsp-180
|
|
CD105
|
Endoglin, Eng
|
95kD
|
|
endoth, BM cell subset, macact
|
response to TGF-β1, ligand for TGF-β, adhesion
|
MJ7/18
|
CD106
|
VCAM-1
|
110kD
|
IgSF
|
endothact, FDC, BM myeloid
|
CD49d/CD29 receptor, adhesion/migration,
costimulation
|
429
|
CD107a
|
LAMP-1
|
120kD
|
|
plateletsact, Tact, endothact
|
adhesion, metastasis
|
eBio1D4B (1D4B)
|
CD107b
|
LAMP-2
|
110kD
|
|
plateletsact, Tact, endothact
|
adhesion, metastasis
|
eBioABL-93 (ABL-93)
|
CDw108
|
Sema7a
|
80kD
|
IgSF, GPI-linked
|
mRNA: nervous system(high), immune system
|
|
|
CD109
|
Gov platelet alloantigen
|
|
|
|
|
|
CD110
|
TPO-R, c-mpl
|
82-84kD
|
CRSF
|
megakaryocytes, platelets
|
thrombopoietin receptor, megakaryocyte differentiation
|
|
CD111
|
PRR1, Nectin-1, Pvrl
|
64-72kD
|
IgSF, ASV
|
fibroblasts, epithelium, neurons
|
polio virus receptor-related protein1, mediates entry of
herpes simplex virus (HSV) strains
|
|
CD112
|
PRR2, Pvs, Nectin-2
|
64-72kD
|
IgSF, ASV
|
mRNA: brain, spinal cord, spleen, kidney, heart, liver
|
intercellular adhesion, not a receptor for poliovirus
|
|
CDw113
|
PVRL3, Nectin3
|
100kD
|
Ig-like, ASV
|
broad, epith
|
adhesion molecule, interacts with afadin
|
|
CD114
|
G-CSFR, Csfgr, Csf3r
|
95, 139kD
|
CRSF
|
progenitor & mature neutrophils, endoth, placenta,
some myeloid leukemia
|
myeloid proliferation & differentiation
|
|
CD115
|
M-CSFR, c-fms, Csf1r
|
150kD
|
RTKF
|
monocytic progenitors, osteoclasts
|
M-CSF receptor, monocytic lineage proliferation/
differentiation, role in differentiation of osteoclasts
|
AFS98
|
CD116
|
GM-Csf2ra
|
70-85kD
|
CRSF
|
mono, gran, DC, endoth
|
low affinity GM-CSF receptor, w/ common β AIC2B form high affinity receptor, myeloid proliferation, differentiation
|
|
CD117
|
c-kit, Steel factor
|
145kD
|
IgSF, RTKF
|
hematopoietic stem & progenitors, neural
crest-derived melanocytes, primordial germ cells,
mast cells
|
Stem Cell Factor receptor, hematopoietic progenitor
development & differentiation, dominant white
spotting (w) mutation
|
2B8
|
|
|
|
|
|
|
ACK2
|
CD118
|
LIFR
|
190kD
|
Type I cytokine receptor family,
ASV
|
placenta, liver, kidney, heart, lung, brain epith
|
membrane-bound involved in signal transduction,
soluble form inhibits activity of LIF
|
|
CDw119
|
IFNγR, ifgr1, Ifngr
|
90-100kD
|
|
mac, mono, B, T, NK, neutrophils,
endoth
|
Interferon-γ receptor α chain, w/ IFNγ AF-1, host defense, high affinity IFNγ binding
|
|
CD120a
|
TNFR1, p55
|
50-60kD
|
TNFRSF
|
broad
|
TNF receptor, binds both TNFα & TNFβ, apoptosis
|
55R-170
|
CD120b
|
TNFR2, p75
|
75-85kD
|
TNFRSF
|
broad
|
TNF receptor, high
affinity binding to TNFα &
TNFβ, apoptosis
|
|
CD121a
|
IL-1R type I
|
80kD
|
IgSF
|
broadlow, fibroblasts, T, brain, pancreas, cardiac endoth, epith, developing oocytes
|
Type I IL-1R, binds IL-1α & IL-1β, IL-1 signaling
|
|
CDw121b
|
IL-1R, type II
|
68kD
|
IgSF
|
B, mac, mono, T subset (Th2), epidermis, dermis,
vaginal basal epith, brain
|
Type II IL-1R, binds IL-1α & IL-1β, a decoy receptor
|
|
CD122
|
IL-2Rβ, p70
|
75kD
|
CRSF
|
NK, T, B, mono
|
IL-2R & IL-15Rβ chain, signaling, w/ CD25 & CD132
form high affinity IL-2R, lymphocyte development
|
5H4
|
|
|
|
|
|
|
TM-b1
|
CDw123
|
IL-3Rα
|
70kD
|
CRSF
|
lymphocyte subset, basophils, hematopoietic
progenitors, mac, DC, megakaryocytes
|
IL-3R α chain, low affinity binding to IL-3, w/ CDw131
form high affinity IL3 binding
|
5B11
|
CD124
|
IL-4Rα
|
140kD
|
CRSF
|
lymphocyteslow, mono, hematopoietic precursors,
fibroblast, epith
|
IL-4Rα chain, w/ CD132 or IL-13Rα chain, w/ CD132
forms high affinity IL-4R, T growth & differentiation,
soluble form
|
|
CDw125
|
IL-5Rα
|
60kD
|
CRSF
|
eosinophils, basophils
|
IL-15Rα chain, w/ CDw131 for low affinity IL-5 binding, w/ β subunit for high affinity IL-15 binding
|
|
CD126
|
IL-6Rα
|
80kD
|
IgSF, CRSF
|
Bact, plasma cells, most leukocyteslow, fibroblasts
|
IL-6Rα subunit, low affinity IL-6 binding, w/ CD130 for
high affinity IL-6 binding, soluble form
|
D7715A7
|
CD127
|
IL-7Rα
|
65-75kD
|
CRSF
|
pro-B, T
|
IL-7Rα chain, w/ CD132 for high affinity IL-7 binding,
T & B development
|
A7R34
|
|
|
|
|
|
|
eBioSB/199
|
CDw128
|
see CD181 and CD182
|
|
|
|
|
|
CD130
|
IL-6Rβ, gp130
|
130kD
|
CRSF
|
broad in adult & embryonic cells
|
Common β chain of IL-6R, IL-11R, LIFR, OSMR
|
KGP130
|
CDw131
|
IL-3R, AIC2B/A, common β, Csf2rb1, Csf2rb2
|
95-120kD
|
CRSF
|
mono, gran, early B
|
2 genes in mouse, signaling, w/ α subunits of IL-3, IL-5, GM-CSF receptors
|
|
CD132
|
IL-2R Common β
|
64kD
|
CRSF
|
T, B, NK, mono, gran, DC
|
Subunit of IL-2, IL-4, IL-7, IL-13, & IL-15R, signaling,
mutation: X-linked SCID
|
mAb (please inquire)
|
CD133
|
Prominin-1, AC133
|
115-120kD
|
TM5 glycoprotein
|
primitive cells like hematopoietic progenitors, neural,
endoth stem cells, retina, retinoblastoma, developing
epith (apical surface)
|
unknown
|
13A4
|
CD134
|
OX-40, Ly-70, Txgp1
|
48-50kD
|
TNFRSF
|
Tact
|
OX-40L receptor, apoptosis, T activation/differentiation
|
OX-86
|
CD135
|
Flt3/Flk2, EMS-like tyr kinase 3
|
130-150kD
|
RTK family
|
hematopoietic progenitors: myeloid & primitive B
progenitors
|
binds FLT3 ligand, myeloid & lymphoid development,
expands hematopoietic progenitors & DC
|
A2F10
|
CDw136
|
STK, Mst1r, RON
|
180kD
|
RTK family
|
hematopoietic cells
|
macrophage stimulatory 1 receptor
|
|
CDw137
|
4-1BB, Tnfrsf9
|
30kD
|
TNFRSF
|
Tact
|
T costimulation, binds to 4-1BBL, fibronectin,
vitronectin, laminin, collagen VI
|
17B5
|
CD138
|
syndecan-1, Sdc1
|
80-150kD
|
Syndecan
|
epith, plasma cells, pre-B, neurons
|
receptor for ECM, cell morphology, B differentiation
|
mAb (please inquire)
|
CD139(H)
|
|
|
|
not defined in mouse
|
|
|
CD140a
|
PDGF receptor α
|
180kD
|
RTK family
|
fibroblasts, smooth muscle, glial
cells, chondrocytes
|
PDGFRaa binds PDGF AA, AB, BB,
PDGFRab binds AB, BB, PDGFRbb binds
PDGFBB, embryonic development,
signaling
|
APA5
|
CD140b
|
PDGF receptor β
|
180kD
|
RTK family
|
fibroblasts, smooth muscle, glial cells,
chondrocytes
|
see CD140a for ligands, signaling
|
APB5
|
CD141
|
Thrombomodulin
|
100kD
|
C-type lectin
|
mono, neutrophils, endoth, smooth muscle
|
initiation of protein C anticoagulant pathway
|
|
CD142
|
Tissue Factor, factorIII, F3
|
45kD
|
mRNA: broad
|
binds clotting factor VIIa, embryonic development
|
|
|
CD143
|
ACE
|
170kD
|
endoth, epith, neuron, fibroblasts, macact
|
peptidyl-peptidase, angiotensin converting enzyme
|
|
|
CD144
|
Cadherin5, VECadherin
|
130kD
|
Cadherins
|
endoth
|
adhesion, intercellular interaction
|
BV13
|
|
|
|
|
|
|
BV14
|
CD146
|
MUC18, S-endo, mcom
|
|
IgSF
|
embryonic tissue, mammary tumors
|
cell adhesion during development
|
|
CD147
|
Neurothelin, basigin, Bsg
|
|
IgSF
|
leukocytesact, erythrocytes, platelets, endoth
|
adhesion, blood-brain barrier
|
RL73
|
CD148
|
HPTP-eta, M4, M56
|
240-260kD
|
|
mRNA: broad, high in brain, kidney
|
tyrosine phosphatase R Type III
|
|
CD150
|
SLAM, IPO-3
|
75kD
|
IgSF
|
T, B, maintained on Th1
|
costimulation, proliferation, Ig production
|
9D1
|
CD151
|
PETA-3, SFA-1
|
32kD
|
TM4SF
|
endoth, megakaryocytes, platelets
|
adhesion, signaling
|
|
CD152
|
CTLA-4, Ly-56
|
33kD
|
IgSF
|
Tact
|
CD80, CD86 receptor, negative T stimulation
|
9H10
|
|
|
|
|
|
|
UC10-4B9
|
CD153
|
CD30L, Tnfsf8
|
40kD
|
TNFSF
|
Tact, macact, neutrophil, B, induced on cardiac myocyte
|
CD30 receptor, T costimulation
|
RM153
|
CD154
|
CD40L, gp39, Ly-62, Tnfsf5
|
32-39kD
|
TNFSF
|
transiently on Tact, B subset (intracellular), platelets
|
CD40 receptor, B & DC costimulation, T activation
|
MR1
|
CD155
|
PVR
|
80-90kD
|
IgSF
|
mono, mac
|
Polio virus receptor
|
|
CD156a
|
ADAM8, MS2
|
69kD
|
Type I TM
|
neutrophils,
mono
|
metalloprotease,
leukocyte
extravasation
|
|
CD156b
|
TACE/
ADAM 17
|
100kD
|
|
broad
|
zinc metalloprotease, TNF converting enzyme
|
|
CDw156c
|
ADAM10, kuz, kuzbanian, Madm
|
60kD
|
Peptidase M12B family
|
neural precursors, fibroblasts
|
proteolytic cleavage of cell-surface molecules
including Notch, TNF-α, APP & ephrin-A2
|
polyclonal
|
CD157
|
BST-1, Ly-65, Bp3
|
38-48kD
|
GPI-linked
|
gran, mono, early B, T subset, BM stroma
|
ADP-ribosyl-cyclic ADP-ribose hydrolase,
pre-B growth
|
|
CD158(H)
|
KIR
|
|
|
not defined in mouse
|
|
|
CD159a
|
NKG2A, Klrc1
|
43kD
|
|
NK & NKT cells
|
w/ CD94, Qa-1(b) receptor, inhibitory signaling
|
20d5
|
CD159c
|
NKG2C
|
|
C-type lectin
|
NK & NKT cells
|
w/ CD94, Qa-1(b) receptor, stimulatory signaling
|
20d5
|
CD160
|
BY55
|
27kD
|
IgSF
|
NK subset, T subset
|
costimulation
|
eBioCNX46-3
|
CD161c
|
NKR-P1c, Ly-55, NK1.1
|
40kD
|
C-type lectin
|
NK, T subset
|
NK cell-mediated cytotoxicity
|
PK136
|
CD162
|
PSGL-1, Slp1
|
120kD
|
Mucin family
|
myeloid cells, lymphocyte subset
|
CD62P & CD62L receptor, adhesion, leukocyte rolling
|
|
CD162R(H)
|
PEN-5
|
|
|
not defined in mouse
|
|
|
CD163
|
|
100-130kD
|
SRCRSF
|
peritoneal mac
|
|
|
CD164
|
MGC-24, A115, A24
|
80kD
|
Sialomucin
|
mRNA: broad various adult & embryonic tissues
|
hematopoietic progenitor-stroma interaction
|
|
CD165
|
AD2, gp37
|
|
|
not defined in mouse
|
|
|
CD166
|
ALCAM
|
120kD
|
IgSF
|
neurons, Tact, mono, epith, fibroblasts
|
CD6 receptor, adhesion, T development,
T-B interaction, role in nervous system
|
eBioALC48
|
CD167a
|
DDR1
|
120kD
|
RTK family
|
epith, myoblasts, brain, early marker neuroectoderma
|
discoidin domain receptor, tyrosine kinase, adhesion
|
|
CD168
|
RHAMM, Hmmr
|
70-73kD
|
|
broad
|
hyaluronan-mediated motility receptor, adhesion, cell
locomotion, tumor metastasis (intracellular in human
breast cancer)
|
|
CD169
|
sialoadhesin, Sn, Siglec-1
|
185kD
|
IgS
|
tissue mac subset
|
adhesion, cell-cell & cell-matrix interactions, binds
α2,3-sialylated ligands CD43, CD227, SRBC-R
|
|
CD170(H)
|
Siglec-5, CD33-like2
|
140kD
|
IgSF,
sialoadhesins
|
mac subset, neutrophils
|
adhesion
|
|
CD171
|
L1, cell adhesion molecule
|
200-210kD
|
IgSF
|
CNS, PNS, glial cells, mono, T subset, B, DC,
lymph node reticular fibroblasts, some epith
|
homotypic adhesion, T co-stimulation, integrin binding,
KO has neuropathologies similar to CRASH disorder
|
|
CD172a
|
SIRPα, Ptpns1
|
110kD
|
IgSF
|
mono, mac, DC, T subset, stem cells
|
adhesion, w/ CD47, SHP substrate-1
|
|
CD172b
|
SIRPβ
|
60-90kD
|
Ig-like Type I cell surface
receptor
|
mac and other hematopoietic lineages
|
engagement of SIRPβ promotes phagocytosis in mac
|
|
CD172g(H)
|
SIRPγ
|
|
|
not defined in mouse
|
|
|
CD173-CD175(H)
|
|
|
CHO
|
|
|
|
CD176
|
Trf, transferring, Tfn, HP
|
|
CHO
|
|
|
|
CD177
|
NB1
|
56-62kD
|
GPI-linked
|
neutrophil subset (surface & intracellular)
|
|
|
CD178
|
Fas Ligand, CD95L,TNFSF6
|
38-42kD
|
TNFSF
|
Tact, testis
|
apoptosis of CD95+ cells, immune privilege, soluble
form in serum, gld mutation nonfunctional FasL
|
MFL3
|
|
|
|
|
|
|
MFL4
|
CD179a
|
V pre B
|
16kD
|
IgSF
|
pro- & early pre-B
|
B differentiation, signaling, pre-BCR w/ IgM/CD79α/β
|
|
CD179b
|
Lambda 5
|
22kD
|
IgSF
|
pro- & early pre-B
|
B differentiation, signaling,
pre-BCR w/ IgM/CD79α/β
|
|
CD180
|
RP105, Ly-78
|
95-105kD
|
LRRF, TLRSF
|
B, mono, DC
|
B recognition & signaling
of LPS, w/ MD-1
|
RP/14
|
CD181
|
CXCR1, IL8Rα
|
39kD
|
GPCR family
|
neutrophils, basophils,
NK, T subset, mono
|
binding of IL-8
induces chemotaxis
of neutrophils
|
|
CD182
|
CXCR2, IL8Rβ
|
40kD
|
GPCR family
|
neutrophils, basophils,
NK, T subset, mono
|
binding of IL-8 induces
chemotaxis of neutrophils,
also binds GRO and NAP-2
|
|
CD183
|
CXCR3, Cmkar3, gpr9
|
40kD
|
TM7SF
|
Tact (Th1), NK, eosinophils, GM-CSF activated hematopoietic progenitors
|
6Ckine, IP-10 , Mig & I-TAC receptor, T recruitment to
inflammatory sites,Th1 response, allograft destruction
|
CXCR3-173
|
CD184
|
CXCR4, Cmkar4, Fusin/LESTR
|
45kD
|
TM7SF
|
T subset, B, DC, mono, endoth
|
SDF-1 receptor, embryogenesis, (human: X4 HIV-1
coreceptor)
|
eBiomCXCR4
|
|
|
|
|
|
|
polyclonal
|
CD185
|
CXCR5, BLR1
|
45kD
|
GPCR family
|
spleen, resting B, T, skin-derived DC
|
binds BLC, involved in B-cell migration into B-cell
follicles of spleen and Peyers patches
|
|
CDw186
|
CXCR6, BONZO
|
40kD
|
GPCR family
|
memory T
|
chemokine receptor for CXCL16, also a coreceptor by
SIVs and by strains of HIV-2 and m-tropic HIV-1
|
|
CD191
|
CCR1, MIP-1αR, RANTES-R
|
39kD
|
GPCR
family
|
neutrophils, mono, lymph, eosinophils & osteoclasts
|
receptor for C-C type chemokines MIP-1α, RANTES,
MIP-1β, MCP-1
|
|
CD192
|
CCR2, MIP-1αR
|
40kD
|
GPCR family
|
T subset, mono, B
|
receptor for the MCP-1, MCP-3 & MCP-4 chemokines
|
|
CD193
|
CCR3, MIP-1αRL2
|
45kD
|
GPCR family
|
skeletal muscle & low amounts in leukocytes, T subset
|
receptor for C-C type chemokines eotaxin, MCP-3,
MCP-4 and RANTES
|
|
CD195
|
CCR5, Cmkbr5
|
45kD
|
TM7SF
|
T subset, NK, monolow
|
MIP-1α, MIP-1β & RANTES receptor, (human: R5
HIV-1 coreceptor)
|
HM-CCR5 (7A4)
|
CD196
|
CCR6, KY411
|
45kD
|
GPCR family
|
mainly B, T and DC subset
|
receptor for C-C type chemokines MIP-3α/LARC
|
|
CD197
|
CCR7, Cmkbr7
|
45kD
|
TM7SF
|
T, DC subset
|
6Ckine & MIP-2β receptor
|
4B12
|
CDw198
|
CCR8, TER1
|
50kD
|
GPCR family
|
mono, mac, neutrophils, T subset
|
receptor for TCA-3/I-309
|
|
CDw199
|
CCR9, CMKBR10
|
43kD
|
GPCR family
|
high in thymus, immature and mature T
|
receptor for chemokine SCYA25/TECK,
role in T development
|
eBioCW-1.2 (CW-1.2)
|
CD200
|
OX-2
|
45-50kD
|
IgSF
|
thymocytes, B, Tact, DC, endoth, neurons
|
T costimulation, regulation of oxidoreductase pathway
|
|
CD201
|
Procr, EPCR
|
50kD
|
|
endoth & stem cell subset
|
activated protein C receptor
|
eBio1560 (1560)
|
CD202b
|
Tie2, Tek
|
140kD
|
RTK family
|
stem cells, endoth from early development
|
angiogenesis, Angiopoietin-1 receptor
|
TEK4
|
CD203c
|
ENpp1, PC-1, TWY
|
115kD
|
Type II TM
|
antibody secreting B,
basophils, mast cells,
megakaryocytes, glioma
|
plasma cell alloantigen,
ectoenzyme, binding/clearance
of extracellular nucleotides
|
|
CD204
|
Macrophage scavenger-R, Scvr
|
220kD
|
|
mac
|
endocytosis of macromolecules
|
|
CD205
|
DEC-205, Ly75
|
205kD
|
mac mannose receptor SF
|
DC, thymic epith, Blow, BM stromal, pulmonary epith, brain capillaries
|
antigen up-take/presentation, immune inhibition
|
205yekta
|
CD206
|
macrophage mannose-R, Mrc1
|
180kD
|
|
mac, mono, DC subset
|
phagocytosis/pinocytosis mannose containing molecules
|
|
CD207
|
Langerin
|
40kD
|
Type II TM
|
Langerhans cells
|
Ag capture & endocytic receptor, w/ Birbeck granules
|
eBioRMUL.2
|
CD208(H)
|
DC-LAMP, Lamp3
|
70-90kD
|
|
DCact, interdigitating DC
|
|
|
CD209
|
DC-SIGN, CIRE
|
44kD
|
|
DC subset
|
ICAM-3 receptor, HIV-1 binding protein,
T-DC interaction
|
5H10
|
|
|
|
|
|
|
LWC06
|
CDw210
|
IL-10R
|
90-110kD
|
|
Th1, B, NK, mono, mast cells, mac
|
IL-10 receptor, signaling, related to IFN receptors
|
|
CD212
|
IL-12Rβ1
|
100kD
|
dimer & oligomer Type I TM
|
Tact, NKact
|
high affinity binding to IL-12, w/ IL-12 receptor β2, signaling, T & NK response to IL-12
|
|
CD213a1
|
IL-13Rα1, NR4
|
65kD
|
CRSF
|
mono, NK, fibroblasts, endoth
|
binds IL-13 low affinity, w/ CD124
|
|
CD213a2
|
IL-13Rα2
|
65kD
|
CRSF
|
B, mono
|
binds IL-13 high affinity
|
|
CDw217
|
IL-17R
|
120kD
|
|
broad
|
IL-17 receptor
|
|
CDw218a
|
IL-18Rα, IL1Rrp
|
70kD
|
IL-1R family
|
T, NK & DCs
|
IL-18 binding leads to the activation of NF-κB
|
|
CDw218b
|
IL-18Rβ, IL18Rap
|
70kD
|
IL-1R family
|
T, NK and DCs
|
forms heterodimeric receptor with IL-18Rα to enhance IL-18 binding
|
|
CD220
|
InsulinR, Insr
|
140 & 70kD
|
RTK family
|
broad
|
Insulin receptor, regulation of metabolism
|
|
CD221
|
IGF-1R
|
140 & 70kD
|
RTK family
|
broad
|
binds IGF high affinity, prolif/differentiation
|
|
CD222
|
IGF-II R, M6P/IGF2R
|
220-250kD
|
Type I TM
|
broad, 90-95% intracellular
|
cation-independent mannose
6-phosphate receptor, TGFβ-LAP, plasminogen & proliferin receptor
|
|
CD223
|
LAG-3
|
70kD
|
IgSF
|
Tact, Nkact
|
MHC class II ligand, role in
natural killing
|
eBioC9B7W
|
|
|
|
|
|
|
polyclonal
|
CD224
|
GGT, Ggtp
|
27, 68kD
|
|
yolk sac, protoplasmic astrocytes,
endoth, embryonic stem cell lines
|
γ-glutamyl transpeptidase
|
|
CD225
|
Ifitm1, fragilis2, Mil2
|
|
|
primordial germ cells
|
adhesion, differentiation, interferon-induced transmembrane protein 1
|
|
CD226
|
DNAM-1, PTA-1, TLiSA1
|
|
IgSF
|
Th1, CD8 T, platelets
|
platelet activation, T differentiation, costimulation, Th1 function
|
eBio10E5
|
CD227
|
Muc1, EMA
|
300kD
|
Mucin family type I TM
|
lymphocytes, tumors, epith, increased in pregnancy
|
epithelial membrane antigen, organogensis
|
|
CD228
|
Melanotransferrin, Mfi2
|
80-95kD
|
TransferrinSF
|
mRNA: cartilage(high), testis(moderate)
|
|
|
CD229
|
Ly-9, Lgp100
|
95, 110kD
|
IgSF
|
thymocytes, T, B, BM subset, not erythrocytes
|
adhesion
|
Ly9ab3
|
CD230
|
Prion protein, PrnP
|
35kD
|
neurons, lymphocytes, other cells
|
Scrapie-associated fibril protein
|
|
|
CD231
|
TALLA-1, A15
|
30-45kD
|
TM4SF
|
mRNA: brain, colon, muscle, heart, kidney, spleen
|
T cell acute lymphoblastic leukemia marker,
neuronal function
|
|
CD232
|
VESP-R, PlexinC1
|
200kD
|
|
broad
|
viral-encoded semaphorin protein receptor
|
|
CD233
|
Band3, SLC4A1
|
90kD
|
Anion exchanger F
|
erythrocytes, mRNA: epith, other tissues
|
anion pump, CO2 transport,
linking membrane to cytoskeleton
|
|
CD234
|
Duffy, Dfy, DARC
|
36-37kD
|
|
mRNA: spleen, BM, liver, brain, not erythrocytes
|
Duffy blood group antigen chemokine receptor
|
|
CD235a
|
Glycophorin A, Gypa
|
36kD
|
|
erythrocytes
|
one gene only in mouse for Glycophorin A
|
|
CD236R
|
Glycophorin C
|
32kD
|
|
erythrocytes
|
|
|
CD238
|
Kell blood group,
Kel
|
110kD
|
|
erythrocytes, mRNA: spleen
|
|
|
CD239(H)
|
B-CAM,
Lu
|
78-85kD
|
IgSF
|
mRNA: broad,
erythrocytes
|
Lutheran blood
group, B adhesion to
laminin
|
|
CD240CE(H)
|
Rhesus
30CE
|
30-32kD
|
|
erythrocytes
|
Rh30CE & RH30D is
one gene in the mouse: RH30
|
|
CD241
|
Rhesus 50, RhAg
|
50kD
|
TM12SF
|
erythrocytes
|
Rh antigens w/ CD47 & LW
|
|
CD242(H)
|
ICAM-4, LW blood group
|
42kD
|
IgSF
|
erythrocytes
|
adhesion, Landsteiner-Wiener blood group
|
|
CD243
|
MDR-1, Abcb1, Pgp
|
170kD
|
|
T subset, stem cells, small intestine, kidney
|
ion pump, cytokine export, CTL function
|
|
CD244
|
2B4, Ly-90, Nmrk
|
78kD
|
Type II TM, IgSF
|
NK, NKT, LAK
|
NK activation, CD48 receptor, MHC-unrestricted killing
|
eBio244F4
|
CD246
|
ALK, Ki-1
|
200kD
|
RTK family
|
mRNA: brain, not normal lymphocytes
|
anaplastic lymphoma kinase, brain development
|
|
CD247
|
TCR ζ, cd3z
|
16kD
|
RTK family
|
T, NK subset
|
TCR subunit, signaling, low level impaired
immune function
|
|
CD248
|
TEM1, Endosialin
|
175kD
|
C-Type Lectin
|
endoth tissue
|
may function in tumor progression and angiogenesis
|
|
CD249(H)
|
Aminopeptidase A
|
|
|
not defined in mouse
|
|
|
CD252
|
OX-40 Ligand, gp34
|
35kD
|
TNFSF
|
Bact, cardiac myocytes
|
T-B interaction, T costimulation
|
RM134L
|
CD253
|
TRAIL, APO-2L
|
|
TNFSF
|
NKact, liver NK
|
apoptosis
|
N2B2
|
CD254
|
TRANCE, RANKL, OPGL
|
~35kD
|
TNFSF
|
Tact, osteoblasts
|
T-DC communication, osteoclast differentiation
|
IK22/5
|
CD256
|
APRIL, TALL-2
|
16kD
|
TNFSF
|
Tact, mono, mac
|
binds TACI and BCMA
|
polyclonal
|
CD257
|
BLyS, BAFF, TALL-1
|
45kD
|
TNFSF
|
mono
|
binds TACI, BCMA & BAFFR to induce B proliferation
|
polyclonal
|
CD258
|
LIGHT, HVEM-L
|
28kD
|
TNFSF
|
Tact, immature DC
|
binds LTBR to induce T proliferation, also binds HVEM
|
mAb (please inquire)
|
CD261(H)
|
TRAIL-R1
|
|
|
not defined in mouse
|
|
|
CD262
|
TRAIL-R2, DR5, Apo2, TRICK2, KILLER
|
|
TNFRSF
|
broad
|
ligand for TRAIL, activates NF-κB & mediates apoptosis, p53-dependent expression
|
MD5-1
|
|
|
|
|
|
|
polyclonal
|
CD263(H)
|
TRAIL-R3
|
|
|
not defined in mouse
|
|
Polyclonal
|
CD264(H)
|
TRAIL-R4
|
|
|
not defined in mouse
|
|
Polyclonal
|
CD265
|
RANK, TRANCE-R, ODFR
|
97kD
|
TNFRSF
|
broad expression
|
binding of TRANCE mediates osteoclastogenesis
& T-DC interactions
|
R12-31
|
CD266
|
TWEAK Receptor, Fn14
|
14kD
|
TNFRSF
|
mRNA in liver regeneration, Colon 26 cell line
|
cell migration, proliferation, angiogenesis, activates
NF-κB pathway
|
ITEM-2
|
|
|
|
|
|
|
ITEM-4
|
CD267
|
TACI, TNFRSF13b
|
32kD
|
TNFRSF
|
Tact and B
|
binding of APRIL or BLyS stimulates B and T function
|
eBio8F10-3
|
CD268
|
BAFFR, Bcmd
|
25kD
|
TNFRSF
|
B
|
BLyS binding promotes survival of mature B
& B response
|
polyclonal
|
|
|
|
|
|
|
eBio7H22-E16
|
CD269
|
BCMA, TNFRSF13B
|
20kD
|
Type III TM, TNFRSF
|
mature B (membrane and perinuclear)
|
binds APRIL, BAFF, survival and proliferation
|
|
CD271
|
NGFR, TNFRSF16, p75 (NTR), Bex3, Ngfrap1
|
45kD
|
TNFRSF
|
neurons, mesenchymal stem cells
|
binds NGF, BDNF, NT-3 and NT-4, tumor supressor
mediate cell survival and death
|
|
CD272
|
BTLA, B & T Lymphocyte Associated
|
33kD
|
IgSF
|
T, B , BM, splenic macs, BM derived DC
|
binds HVEM, negative regulation
|
6F7 (blocking)
|
|
|
|
|
|
|
3F9.D12
|
|
|
|
|
|
|
6H6
|
|
|
|
|
|
|
6G3
|
|
|
|
|
|
|
8F4 (non-blocking)
|
CD273
|
B7DC, PD-L2, PDCD1L2
|
25kD
|
IgSF
|
DC subset, mono, mac
|
binds PD-1, co-stimulation or supression of
T cell proliferation
|
TY25
|
|
|
|
|
|
|
122
|
CD274
|
B7-H1, PD-L1, PDCD1LG1
|
33kD
|
IgSF
|
leukocytes, decrease in mature thymic T cells
|
binds PD-1, proliferation and cytokine production
|
MIH5
|
|
|
|
|
|
|
1-111A
|
CD275
|
B7-H2, GL50, ICOS-L, B7h, B7RP-1
|
60kD
|
B7 family
|
APC, B, DC, mac
|
lymphocyte costimulation, receptor for ICOS
|
HK5.3
|
CD276
|
B7-H3, B7RP-2
|
40-45kD
|
B7 family
|
in vitro cultured DC and mono
|
negative regulator of T cell activation
|
M3.2D7
|
CD277(H)
|
BT3.1
|
|
|
not defined in mouse
|
|
|
CD278
|
ICOS, Inducible T cell COStimulator , Ly115
|
55-60kD
|
CD28 family
|
Tact, Th2
|
T costimulation, B7-H2 receptor, cytokine production
|
7E.17G9
|
|
|
|
|
|
|
C398.4A
|
|
|
|
|
|
|
15F9
|
CD279
|
PD-1, programmed death-1
|
55kD
|
IgSF
|
Tact, Bact
|
negatively regulates lymphocytes, T cell
development
|
J43
|
|
|
|
|
|
|
RMP1-14
|
|
|
|
|
|
|
RMP1-30
|
CD280
|
ENDO180,
UPARAP, MRC2
|
180kD
|
CD28 family
|
chondrocytes
|
binds uPAR, mannose
receptor, collagen matrix
remodeling & endocytic recycling
|
|
CD281
|
TLR1
|
90kD
|
TLR family
|
low levels in leukocytes
|
innate immunity, w/ TLR2
|
eBioTR23
|
|
|
|
|
|
|
eBioLD5
|
CD282
|
TLR2
|
90kD
|
TLR family
|
myeloid lineage: mac & DC in spleen
|
response to bacterial lipoproteins
|
6C2
|
|
|
|
|
|
|
T2.5
|
|
|
|
|
|
|
mT2.7
|
|
|
|
|
|
|
polyclonal
|
CD283
|
TLR3
|
100kD
|
TLR family
|
DC subset, mac, fibroblasts, induced by LPS
|
binds dsRNA, activation of NK-κB
|
T3.7C3
|
|
|
|
|
|
|
polyclonal
|
CD284
|
TLR4, Ly87, Rasl2-8
|
100kD
|
TLR family, ASV
|
thioglycolate-elicited peritoneal mac
|
binds LPS, innate immunity
|
MTS510
|
|
|
|
|
|
|
UT41
|
|
|
|
|
|
|
UT12
|
|
|
|
|
|
|
UT18
|
|
|
|
|
|
|
polyclonal
|
CD289
|
TLR9
|
120kD
|
TLR family
|
DC subset (intracellular)
|
binds CpG-DNA
|
m9.D6
|
|
|
|
|
|
|
polyclonal
|
CD292
|
BMPR1A, ALK3
|
57kD
|
Type I, BMP receptor
|
bone progenitor, broad
|
binds BMP 2 & 4, bone development, germ layer
specification
|
|
CDw293
|
BMPR1B, ALK6
|
57kD
|
Type I, BMP receptor
|
bone progenitor, developing retina
|
binds BMP, bone development, neurogenesis
|
|
CD294
|
CRTH2, GPR44
|
55-70kD
|
GPCR-7TM
|
Th2, eosinophils, basophils
|
binds prostaglandin D2, chemotaxis
|
|
CD295
|
LeptinR, LEPR
|
132kD
|
Type I cytokine-like
receptor, ASV
|
broad
|
adipose metabolism, may be involved in immune
dysfunction in obesity
|
|
CD296
|
ART1, RT6, ART2
|
37kD
|
ADP-ribosyltransferase
|
heart and skeletal muscle, peripheral T, NK subset
|
GPI linked protein modifies integrin during differentiation
|
|
CD297
|
ART4, dombrock blood group
|
38kD
|
ADP-ribosyltransferase
|
heart, lung, liver, and spleen, erythroid, monoact
|
|
|
CD298
|
Na+/K+-ATPase β3 subunit, ATP1B3
|
52kD
|
|
broad
|
transporter
|
|
CD299(H)
|
DC-SIGN-related
|
|
|
not defined in mouse
|
|
|
CD301-302 (H)
|
|
|
|
not defined in mouse
|
|
|
CD303
|
Clecsf10, dectin-2
|
|
C-type lectin domain family 4
|
tissue mac, DC, upregulated on blood mono
|
inflammatory lesion, UV-induced tolerance
|
|
CD304
|
BDCA4, neuropilin 1, Nrp, NP-1
|
130kD
|
semaphorin family
|
DC, neurons, endoth & tumor cells, CD4+/CD25+ Treg
|
binds VEGF165, semaphorins, coreceptor w/ plexin,
axonal guidance, angiogenesis, cell survival, migration
|
polyclonal
|
CD305
|
LAIR1
|
32-40kD
|
IgSF, ASV
|
broad, NK, B, T, mono
|
inhibitory receptor on NK and T cells
|
113
|
CD306-307(H)
|
|
|
|
not defined in mouse
|
|
|
CD309
|
VEGFR2, Flk-1, KDR
|
230kD
|
Type III TM tyr kinase
|
endoth, angiogenic precursor cells; hemangioblast
|
binds VEGF, regulates adhesion and cell signaling
|
Avas12a1
|
CD312(H)
|
EMR2
|
|
|
not defined in mouse
|
|
|
CD314
|
NKG2D, KLRK1
|
42kD
|
Type II lectin-like receptor
|
NK, CD8+ activated, not CD4+ in the periphery, macact
|
binds MHC class I, Rae1 & ULBP4, cytolysis and cytokine production; costimulatory
|
CX5 (blocking)
|
|
|
|
|
|
|
MI6 (blocking)
|
|
|
|
|
|
|
C7 (blocking)
|
|
|
|
|
|
|
A10 (activating)
|
CD315
|
CD9P1, SMAP6, FPRP, PTGFRN
|
135kD
|
IgSF
|
B subset, monoact
|
w/ CD81 and CD9
|
|
CD316
|
EWI2, PGRL, KASP
|
63-75kD
|
TM4SF, IgSF8
|
B, T, low on NK cells
|
w/ CD81 & CD9; involved in cell migration
|
|
CD317
|
BST2
|
30-36kD
|
Type II
|
BM stromals, fibroblasts, plasmacytoid DC
|
pre-B cell growth, overexpressed in multiple myeloma
|
eBio129c1
|
|
|
|
|
|
|
eBio927
|
CD318
|
CDCP1, CUB domain containing protein 1
|
|
|
|
|
|
CD319
|
CRACC, SLAMF7
|
66kD
|
Ig TM
|
predicted: T, B and DC subset, NK, upregulated in DC
|
regulate T and NK cells
|
|
CD320
|
|
|
8D6, VLDL
|
|
|
|
CD321
|
JAM1, F11 receptor, KAR
|
12.5kD
|
IgSF, Type I,
AVS
|
epith and endoth, platelets
|
tight junction, binds reovirus & LFA1, platelet receptor
|
|
CD322
|
JAM2, VE-JAM
|
45kD
|
IgSF
|
HEV and other endothelia
|
mediates transendothelial migration of lymphocytes
|
|
CD324
|
E-Cadherin, Uvomorulin
|
120kD
|
cadherin SF
|
non-neural epith
|
binding to integrin αE/β7 & homotypic interactions mediate cell adhesion
|
DECMA-1
|
CDw325
|
N-Cadherin, Cadherin-2
|
140kD
|
cadherin SF
|
brain, skeletal & cardiac muscle
|
adhesion, may be involved in neuronal recognition
mechanism
|
|
CD326
|
Ep-CAM, EGP, Ly-74
|
40kD
|
thymocytes, epith, DC
|
may function as growth factor receptor or adhesion
molecule
|
|
|
CDw327(H)
|
siglec6
|
|
|
not defined in mouse
|
|
|
CDw328(H)
|
siglec7
|
|
|
not defined in mouse
|
|
|
CDw329
|
siglec9, siglecl1
|
|
IgSF
|
monocyte/myeloid cells
|
mediates sialic-acid dependent binding to cells
|
|
CD331
|
FGFR1, FLT2, N-SAM
|
30kD
|
TM tyr kinase
|
fibroblasts, epithelial
|
binds FGF, wound healing, bone development
|
|
CD332
|
FGFR2, KGFR, KSAM
|
115-135kD
|
TM tyr kinase
|
fibroblasts, epithelial, ectoderm of embryo
|
binds FGF, embryonic limb development, AER
|
|
CD333
|
FGFR3, ACH, CEK2
|
115kD
|
TM tyr kinase, ASV
|
fibroblasts, epithelial, astrocytes
|
binds FGF, bone & CNS development
|
|
CD334
|
FGFR4, TKF
|
110kD
|
TM tyr kinase
|
fibroblasts, epithelial, hepatocytes
|
binds FGF, bone development
|
|
CD335
|
NKp46, Ly-94 homolog
|
46kD
|
IgSF
|
NK
|
binds non-MHC, NK activation
|
29A1.4
|
CD336(H)
|
NKp44
|
|
|
not defined in mouse
|
|
|
CD337(H)
|
Ncr3, IC7, Ly117
|
|
|
mouse IC7 mRNA in liver
|
|
|
CDw338
|
ABCG2, Mxr, ABC15, BCRP1
|
73kD
|
GPCR 7TM
|
stem cell subset (side population)
|
Multi-drug resistance transporter
|
|
CD339
|
Jagged-1, Serrate1
|
135kD
|
EGF TM
|
BM stromal & mac, stromal cell lines
|
receptor for Notch-1, 2, & 3, hematopoiesis, Th2 fate
|
|
Table 2: Mouse non-CD Cellular Antigens
Mouse non-CD Cellular Antigens
|
Antigen Name |
Other Names |
MW |
Structure |
Distribution |
Function |
eBioscience Clone |
|
|
|
|
|
|
B2D
|
4-1BBL
|
Tnfsf9
|
|
TNFSF
|
Bact, DCact, peritoneal macact
|
DC activation, cytokine production
|
TKS-1
|
33D1 antigen
|
DC-specific marker
|
|
|
DC subpopulations
|
upregulated by GM-CSF, downregulated by IL-4
|
33D1
|
AA4.1 antigen
|
see CDw93
|
|
|
|
|
|
ABCG2
|
see CDw338
|
|
|
|
|
|
AC133
|
see CD133
|
|
|
|
|
|
AID
|
Aicda
|
|
RNA-editing deaminase family
|
Germinal Center B (low to undetectable levels)
|
Activation-Induced Deaminase, Ig class switch recombination
|
eBio961
|
|
|
|
|
|
|
eBio911
|
B7-DC
|
see CD273
|
|
|
|
|
|
B7-H1
|
see CD274
|
|
|
|
|
|
B7-H2
|
see CD275
|
|
|
|
|
|
B7-H3
|
see CD276
|
|
|
|
|
|
B7-H4
|
B7S1, B7x, GPI-linkedF3
|
|
|
T, B, mono, DC subsets
|
lymphocyte costimulation
|
eBioMIH29 (MIH29)
|
|
|
|
|
|
|
clone 9
|
|
|
|
|
|
|
188
|
BP-1
|
Ly-51, 6C3, Enpep
|
120-160kD
|
Type II TM
|
early B progenitors, BM stromal cells, thymic epith
|
zinc metalloproteinase, glutamyl aminopeptidase
|
6C3
|
|
|
|
|
|
|
FG35.4
|
BTLA
|
see CD272
|
|
|
|
|
|
CCR7
|
see CD197
|
|
|
|
|
|
CIRE
|
see CD209
|
|
|
|
|
|
c-Met
|
Met, HGFR/SFR, Par4
|
190kD
|
heterodimer, PTK
|
epith, hematopoietic progenitors, early thymocytes, not detected in adult tissues
|
tumor growth/matastasis, Hepatocyte Growth Factor/Scatter Factor receptor, T development, hematopoiesis
|
eBioclone 4
|
|
|
|
|
|
|
eBioclone 7
|
CMKLR1
|
chemokine-like receptor 1
|
42kD
|
GPCR 7TM
|
pDC (CD123+), in vitro derived moDC
|
binds chemerin, pDC reruitment, may be involved
in bone development
|
mAb (please inquire)
|
DC maturation marker
|
|
|
|
mature DC, B, intracellular granules
|
|
eBio2A1
|
DR5
|
see CD262
|
|
|
|
|
|
DX5
|
see CD49b
|
|
|
|
|
|
F4/80 antigen
|
Emr1, pan-macrophage marker
|
125kD
|
TM7
|
resident tissue mac, liver Kupffer cells, not blood mono, distinguishes mono/mac from fibroblasts
|
macrophage maturation
|
BM8
|
FIRE
|
emr4
|
90-100kD
|
EGF-7TM
|
mac, neutrophilsact, BM derived DC
|
myeloid-B cell interaction
|
6F12
|
Flk-1
|
see CD309
|
|
|
|
|
|
Flt-4
|
VEGFR3
|
170kD
|
RTK family
|
lymphatic endoth
|
endoth growth factor receptor, binds VEGF-C
|
AFL4
|
Foxp3
|
SCURFIN
|
50kD
|
Fox family forkhead
|
T cells (CD4+/CD25+ subset and CD8+ subset)
|
transcription factor, may be upregulated in T regs
|
FJK-16s
|
|
|
|
|
|
|
eBio7979
|
|
|
|
|
|
|
NRRF-30
|
|
|
|
|
|
|
150D/E4
|
GITR
|
AITR, Tnfrsf18
|
30kD
|
TNFRSF
|
T subset, Tact
|
costimulator for CD4+CD25+ Treg subset, induction of apoptosis, regulation of Treg and mucosal immunity
|
DTA-1
|
GITRL
|
AITRL, Tnfsf18 TNFSF
|
|
|
DC, Mac, B
|
costimulation for T subset
|
eBioYGL386
|
Granzyme B
|
CCP1, Ctla1,
Gzmb
|
30kD
|
|
cytotoxic granules of NK & CTL (CD8+)
|
proteolysis, induction of perforin-mediated apoptosis
|
16G6
|
|
|
|
|
|
|
GB11
|
HVEM
|
TNFRSF14, TR2
|
60kD
|
TNFRSF
|
broad expression
|
receptor for LIGHT, LTα, BTLA, Herpes Simplex Virus, involved in lymphocyte activation
|
mAb (please inquire)
|
ICOS
|
see CD278
|
|
|
|
|
|
IgD
|
|
|
|
peripheral mature B cells
|
|
11-26c
|
|
|
|
|
|
|
activating polyclonal
|
IgE Receptor high affinity
|
FcεRIα
|
|
|
basophils, eosinophils, mono, mast, & Langerhans cells
|
high affinity binding to IgE
|
MAR-1
|
IgM
|
|
|
|
surface expression by mature B cells
|
|
II/41
|
|
|
|
|
|
|
eB121-15F9
|
IL-15R\alpha
|
|
|
|
Tact, dim expression
|
binds to IL-15, w/ IL-2Rβ and common γ, IL-15 trans-presentation
|
mAb (please inquire)
|
IL-21R
|
|
|
|
broad on T, B, NK, DC
|
induction of apoptosis in B, expansion of CD3 activated T, NK activation, inhibition of DC
|
eBio4A9
|
Jagged-1
|
see CD339
|
|
|
|
|
|
JAML
|
JAM family
|
|
IgSF
|
neutrophils, mono
|
junctional adhesion molecule 1-like protein, cell contact, neutrophil migration, binds to CAR (coxsackie and adenovirus receptor)
|
eBio4E10
|
KLRG1
|
MAFA
|
30-38kD
|
|
NK & T subset
|
inhibition of cytokine production and cytotoxicity
|
2F1
|
LT\betaR
|
Tnfrsf3
|
47kD
|
TNFRSF
|
mast, stromal cells, epith
|
lymphoid organ development
|
eBio3C8
|
Ly-6A/E
|
Sca-1
|
18kD
|
GPI-linked
|
hematopoietic progenitors, myeloid subset, peripheral
lymphoid, mast cells
|
T activation
|
D7
|
Ly-6B
|
|
|
|
|
|
|
Ly-6C
|
|
14-17kD
|
GPI-linked
|
endoth, T, NK, mono, mac
|
|
|
Ly-6D
|
ThB, Ly-61
|
15kD
|
GPI-linked
|
B, T, thymic epith
|
|
|
Ly-6F
|
|
|
|
|
|
|
Ly-6G
|
Gr-1
|
21-25kD
|
GPI-linked
|
myeloid cells, upregulated in gran
|
|
RB6-8C5
|
Ly-49A
|
A1, Klra1
|
85kD
|
Type II TM C-type lectin
|
T subset, NK subset
|
regulation of cytotoxicity, binds MHC class I
|
eBio12A8
|
Ly-49B
|
Klra2
|
|
|
|
|
|
Ly-49C
|
Klra3, 5E6
|
110kD
|
Type II TM C-type lectin
|
T subset, NK subset
|
regulation of cytotoxicity, binds MHC class I
|
14B11
|
Ly-49D
|
Klra4
|
|
Type II TM C-type lectin
|
NK subset
|
NK activation
|
eBio12A8
|
|
|
|
|
|
|
eBio4E5
|
Ly-49E
|
Klra5
|
|
|
|
|
|
Ly-49F
|
Klra6
|
|
|
|
|
14B11
|
Ly-49G
|
LGL1, Klra7
|
85kD
|
Type II TM C-type lectin
|
T subset, NK subset
|
regulation of cytotoxicity
|
AT8
|
|
|
|
|
|
|
eBio4D11
|
Ly-49H
|
Klra8
|
Type II TM C-type lectin
|
|
|
|
14B11
|
Ly-49I
|
Klra9
|
Type II TM C-type lectin
|
|
|
|
14B11
|
|
|
|
|
|
|
YLI-90
|
Mac-3
|
|
93-110kD
|
|
mac (surface & intracellular) related to CD107b
|
|
M3/84
|
MAdCAM-1
|
|
50kD
|
IgSF, Type I TM
|
endoth subset
|
mucosal vascular addressin cell adhesion molecule, adhesion, lymph homing, binds CD49d & CD62L
|
MECA-367
|
MCP-1
|
monocyte chemoattractant protein; CCL2
|
16kD
|
|
splenocytes
|
chemoattractant for mac and basophils
|
4E2
|
|
|
|
|
|
|
2H5
|
MD-1
|
Ly86
|
28kD
|
|
mature B, mono/mac, DC
|
w/ RP105 (CD180), regulates CD180 surface expression & B cell response to LPS, also secreted
|
MD14
|
|
|
|
|
|
|
MD113
|
Nanog
|
|
|
|
embryonic stem cells
|
transcription factor, ES self renewal
|
eBioM320
|
NKG2A
|
see CD159a
|
|
|
|
|
|
NKG2A^{B6^}
|
CD159a, Klrc1
|
38kD
|
C-type lectin
|
C57BL/6 mouse strain
|
w/ CD94, Qa-1(b) receptor, inhibitory signaling
|
16a11
|
NKG2B
|
|
|
C-type lectin
|
splice variant of NKG2A
|
|
|
NKG2C
|
see CD159c
|
|
|
|
|
|
NKG2D
|
see CD314
|
|
|
|
|
|
NKG2E
|
|
|
C-type lectin
|
NK & NKT cells
|
w/ CD94, Qa-1(b) receptor, stimulatory signaling
|
20d5
|
Notch-1
|
Lin-12, Tan1
|
|
|
developing embryo, variety of adult tissues
|
cell-cell interaction, cell fate determination
|
mN1A
|
OX-40 Ligand
|
see CD252
|
|
|
|
|
|
PD-1
|
see CD279
|
|
|
|
|
|
Perforin
|
Perforin1, Pfp, Prf1
|
70kD
|
|
intracellular, NK and CTL (CD8+)
|
cytolysis, apoptosis
|
eBioOMAK-D
|
Plexin B2
|
Plxnb2, Debt
|
Semaphorin/Plexin Family
|
|
mRNA in nervous system
|
|
eBio3E7
|
Prominin-1
|
see CD133
|
|
|
|
|
|
RAE-1\gamma
|
|
|
|
mRNA in early embryo, not adult tissues; upregulated
by retinoic acid or certain disease conditions,
RAE-1α, -β, and -γ are expressed in BALB/c mice,
but not in C57BL/6, whereas RAE-1δ and -ε are
expressed in C57BL/6 mice
|
ligand for NKG2D
|
CX1
|
RANK
|
see CD265
|
|
|
|
|
|
ROR\gamma(t)
|
|
58kD
|
ROR family Transcription Factor
|
Th17 cells, thymus
|
transcriptional regulation
|
AFKJS-9
|
SAP
|
SLAM-associated protein
|
14kD
|
adaptor protein
|
T, NK
|
negatively regulates SLAM-family receptors
|
eBio5G8
|
|
|
|
|
|
|
eBio1B2
|
Sca-1
|
see Ly6-A/E
|
|
|
|
|
|
Sema4A
|
Sema b, SemB
|
semaphorin family
|
|
DC, B, Tact
|
T constimulation, may not be ligand for Tim-2?
|
KL-1 (aka SK31)
|
SLP-76
|
|
76kD
|
|
T, low in B
|
T cell receptor mediated signaling
|
MS76
|
SSEA-1
|
stage-specific embryonic antigen-1
|
|
|
mouse ES cells, embryonic carcinomas, germ cells
|
down regulated by differentiation
|
eBioMC-480 (MC-480)
|
T-bet
|
|
|
|
Th1 cells
|
transcription factor, T development/differentiation
|
eBioT422
|
TCR \alpha\beta
|
|
|
|
T subset
|
antigen recognition
|
H57-597
|
TCR \gamma\delta
|
|
|
|
T subset
|
antigen recognition
|
GL3
|
|
|
|
|
|
|
UC7-13D5
|
TCR-HY
|
|
|
|
Transgenic H-Y T cells
|
|
T3.70
|
Ter-119
|
Ly-76
|
|
|
early proerythroblast to mature erythrocyte
|
w/ glycophorinA, but not a typical glycophorin
|
TER-119
|
Tie2
|
see CD202b
|
|
|
|
|
|
TIM-1
|
Timd1, Havcr1
|
|
Type I TM, IgSF
|
mRNA activated T cells
|
|
RMT1-4
|
|
|
|
|
|
|
RMT1-10
|
TIM-2
|
Timd2
|
|
Type I TM, IgSF
|
mRNA activated T cells
|
receptor for Sema4A
|
RMT2-1
|
|
|
|
|
|
|
RMT2-14
|
TIM-3
|
Th1-speci.c marker,
Havcr2
|
|
Type I TM
|
late stage of T cell differentiation, CD4+ Th1, CD8+ Tc1
|
effector function of Th1, macrophage activation, regulation of autoimmunity, hepatitis A virus cellular receptor 2
|
8B.2C12
|
|
|
|
|
|
|
RMT3-23
|
TLR1 - TLR4
|
see CD281 - CD284
|
|
|
|
|
|
TLR5
|
|
|
|
mRNA: liver, lung, lower level in MOLF/Ei mice
|
Gram-negative bacterial infection
|
|
TLR6
|
|
|
|
mRNA: spleen, thymus, ovary, lung
|
activation of NF-κB & JunK
|
|
TLR7
|
PRO285
|
125kD
|
TLR family
|
many tissues, DC subset
|
innate immune response to microbial agents
|
polyclonal
|
TLR8
|
PRO286
|
126kD
|
TLR family
|
many tissues, DC subset
|
innate immune response to microbial agents
|
polyclonal
|
TLR9
|
see CD289
|
|
|
|
|
|
TLR11
|
|
|
|
|
|
polyclonal
|
TLR13
|
|
|
|
|
|
mAb (please inquire)
|
TRAIL
|
see CD253
|
|
|
|
|
|
TRANCE
|
see CD254
|
|
|
|
|
|
TWEAK
|
TNF-related weak inducer of apoptosis
|
|
TNFSF, Type II TM
|
mRNA in many adult and fetal tissues
|
membrane-bound and secreted forms, apoptosis, binds Fn14
|
MTW-1
|
TWEAK Receptor
|
see CD266
|
|
|
|
|
|
ZAP-70
|
TCRζ-associated kinase
|
70kD
|
Syk family
|
T (intracellular), NK
|
TCR signaling & development
|
1E7.2
|
References:
Alexa FluorŽ and Pacific BlueŽ are registered trademarks of and licensed under patents assigned to Molecular Probes, Inc. for research use only.
|