Use of horseradish peroxidase to study the antagonism of Clostridium welchii (Cl. perfringens) type D epsilon toxin in mice by the formalinized epsilon prototoxin
D Buxton - Journal of comparative Pathology, 1976 - Elsevier
Intravenously administered horseradish peroxidase was shown to leak from the brain
vasculature of mice which had received lethal doses of Clostridium welchii (Cl. perfringens)
Type D ε-toxin. This leakage was prevented by the prior administration of formalinized ε-
prototoxin, but the inhibition was relatively short lived. It is suggested that ε-toxin may exert
its effect through specific receptor sites on the vascular endothelium. Antigenically similar
formalinized ε-prototoxin blocks this effect.
vasculature of mice which had received lethal doses of Clostridium welchii (Cl. perfringens)
Type D ε-toxin. This leakage was prevented by the prior administration of formalinized ε-
prototoxin, but the inhibition was relatively short lived. It is suggested that ε-toxin may exert
its effect through specific receptor sites on the vascular endothelium. Antigenically similar
formalinized ε-prototoxin blocks this effect.