The long-term effects of placebo in patients with chronic schizophrenia

RJ Wyatt, ID Henter, JJ Bartko - Biological psychiatry, 1999 - Elsevier
Background: It has been hypothesized that placebo periods may increase long-term
morbidity for patients with schizophrenia. In this study, the long-term effect of a placebo
period was evaluated in a group of relatively treatment-refractory patients with chronic
schizophrenia. Methods: This retrospective study examined behavioral rating scores for 127
patients with chronic schizophrenia who were placed in a double-blind placebo study on the
inpatient units of the National Institute of Mental Health Neuropsychiatric Research Hospital …