Several lines of investigation have contributed to the increasing recognition of the biological
basis of psychiatric disorders. Symptom provocation studies have made important
contributions toward this. With the emergence of novel methodologies, the role of symptom
provocation studies has come under increasing scrutiny and debate. The scientific
contributions and risks of symptom provocation studies are discussed using the
psychostimulant paradigm in schizophrenia research as the prototypical study. The …