Sex-related differences in immune development and the expression of atopy in early childhood
SJ Uekert, G Akan, MD Evans, Z Li, K Roberg… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: Sex and age are known to influence the clinical expression of asthma and
allergic diseases. OBJECTIVE: We sought to evaluate whether immune response profiles
also vary by sex and age. METHODS: We performed a prospective birth cohort study
(Childhood Origins of Asthma) designed to evaluate interactions among age, sex, immune
responses, and virus infections on the development of asthma and allergic diseases. Two
hundred eighty-nine subjects were enrolled at birth, and 275 maintained prospective follow …
allergic diseases. OBJECTIVE: We sought to evaluate whether immune response profiles
also vary by sex and age. METHODS: We performed a prospective birth cohort study
(Childhood Origins of Asthma) designed to evaluate interactions among age, sex, immune
responses, and virus infections on the development of asthma and allergic diseases. Two
hundred eighty-nine subjects were enrolled at birth, and 275 maintained prospective follow …