Neuroleptic withdrawal in schizophrenic patients: a review of the literature
PL Gilbert, MJ Harris, LA McAdams… - Archives of general …, 1995 - jamanetwork.com
In the treatment of chronic schizophrenia, there are risks associated with both neuroleptic
maintenance (eg, tardive dyskinesia) and neuroleptic withdrawal (eg, psychotic
exacerbation or relapse). We reviewed 66 studies on neuroleptic withdrawal involving 4365
patients with schizophrenia. The mean cumulative relapse rate was 53% in patients
withdrawn from neuroleptic therapy and 16% in those maintained on neuroleptic therapy
over a mean follow-up period of 9.7 months. The relapse rate was positively associated with …
maintenance (eg, tardive dyskinesia) and neuroleptic withdrawal (eg, psychotic
exacerbation or relapse). We reviewed 66 studies on neuroleptic withdrawal involving 4365
patients with schizophrenia. The mean cumulative relapse rate was 53% in patients
withdrawn from neuroleptic therapy and 16% in those maintained on neuroleptic therapy
over a mean follow-up period of 9.7 months. The relapse rate was positively associated with …