Non-transferrin-bound iron in plasma following administration of oral iron drugs
B Dresow, D Petersen, R Fischer, P Nielsen - Biometals, 2008 - Springer
B Dresow, D Petersen, R Fischer, P Nielsen
Biometals, 2008•SpringerNon-transferrin-bound iron (NTBI) was detected in serum samples from volunteers with
normal iron stores or from patients with iron deficiency anaemia after oral application of
pharmaceutical iron preparations. Following a 100 mg ferrous iron dosage, NTBI values up
to 9 μM were found within the time period of 1–4 h after administration whereas transferrin
saturation was clearly below 100%. Smaller iron dosages (10 and 30 mg) gave lower but
still measurable NTBI values. The physiological relevance of this finding for patients under …
normal iron stores or from patients with iron deficiency anaemia after oral application of
pharmaceutical iron preparations. Following a 100 mg ferrous iron dosage, NTBI values up
to 9 μM were found within the time period of 1–4 h after administration whereas transferrin
saturation was clearly below 100%. Smaller iron dosages (10 and 30 mg) gave lower but
still measurable NTBI values. The physiological relevance of this finding for patients under …
Abstract
Non-transferrin-bound iron (NTBI) was detected in serum samples from volunteers with normal iron stores or from patients with iron deficiency anaemia after oral application of pharmaceutical iron preparations. Following a 100 mg ferrous iron dosage, NTBI values up to 9 μM were found within the time period of 1–4 h after administration whereas transferrin saturation was clearly below 100%. Smaller iron dosages (10 and 30 mg) gave lower but still measurable NTBI values. The physiological relevance of this finding for patients under iron medication has to be elucidated.
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