Diminished concentrations of ganglioside N-acetylneuraminic acid (G-NeuAc) in cerebellum of young rats receiving chronic administration of methylmalonic acid
M Wajner, EC Brites, JC Dutra, MS Buchalter… - Journal of the …, 1988 - Elsevier
Sustained levels of methylmalonate comparable to those of human methylmalonic acidemia
were achieved in the blood of young rats from the 5th till the 25th day of life by injecting them
subcutaneously with buffered methylmalonic acid (MMA) twice a day at 8-h intervals. A
matched group of rats (controls) was treated with saline. The animals were weighed and
killed by decapitation at 25 days of age. Cerebellum and cerebrum were weighed and their
contents of protein, DNA and ganglioside N-acetylneuraminic acid (G-NeuAc), as well as the …
were achieved in the blood of young rats from the 5th till the 25th day of life by injecting them
subcutaneously with buffered methylmalonic acid (MMA) twice a day at 8-h intervals. A
matched group of rats (controls) was treated with saline. The animals were weighed and
killed by decapitation at 25 days of age. Cerebellum and cerebrum were weighed and their
contents of protein, DNA and ganglioside N-acetylneuraminic acid (G-NeuAc), as well as the …