Antipsychotic dose equivalents and dose-years: a standardized method for comparing exposure to different drugs

NC Andreasen, M Pressler, P Nopoulos, D Miller… - Biological …, 2010 - Elsevier
BACKGROUND: A standardized quantitative method for comparing dosages of different
drugs is a useful tool for designing clinical trials and for examining the effects of long-term
medication side effects such as tardive dyskinesia. Such a method requires establishing
dose equivalents. An expert consensus group has published charts of equivalent doses for
various antipsychotic medications for first-and second-generation medications. These charts
were used in this study. METHODS: Regression was used to compare each drug in the …