Childhood-onset schizophrenia: a double-blind clozapine-haloperidol comparison
S Kumra, JA Frazier, LK Jacobsen… - Archives of general …, 1996 - jamanetwork.com
Background: Childhood-onset schizophrenia is a rare but severe form of the disorder that is
often treatmentrefractory. In this study, the efficacy and adverse effects of clozapine and
haloperidol were compared for children and adolescents with early-onset schizophrenia.
Methods: Twenty-one patients (mean [±SD] age, 14.0±2.3 years) with onset ofDiagnostic
and Statistical Manual of Mental Disorders, Revised Third Edition—defined schizophrenia
that began by age 12 years and who had been nonresponsive to typical neuroleptics …
often treatmentrefractory. In this study, the efficacy and adverse effects of clozapine and
haloperidol were compared for children and adolescents with early-onset schizophrenia.
Methods: Twenty-one patients (mean [±SD] age, 14.0±2.3 years) with onset ofDiagnostic
and Statistical Manual of Mental Disorders, Revised Third Edition—defined schizophrenia
that began by age 12 years and who had been nonresponsive to typical neuroleptics …