Childhood-onset schizophrenia: a double-blind, randomized clozapine-olanzapine comparison
P Shaw, A Sporn, N Gogtay, GP Overman… - Archives of General …, 2006 - jamanetwork.com
Background Childhood-onset schizophrenia is a rare but severe form of the disorder that is
frequently treatment resistant. The psychiatrist has a limited evidence base to guide
treatment, particularly as there are no trials in children comparing atypical antipsychotics, the
mainstay of current treatment. Objective To compare the efficacy and safety of olanzapine
and clozapine, hypothesizing that clozapine would be more efficacious. Design Double-
blind randomized 8-week controlled trial, with a 2-year open-label follow-up. Setting …
frequently treatment resistant. The psychiatrist has a limited evidence base to guide
treatment, particularly as there are no trials in children comparing atypical antipsychotics, the
mainstay of current treatment. Objective To compare the efficacy and safety of olanzapine
and clozapine, hypothesizing that clozapine would be more efficacious. Design Double-
blind randomized 8-week controlled trial, with a 2-year open-label follow-up. Setting …