Characterization of the high affinity binding of epsilon toxin from Clostridium perfringens to the renal system
J Dorca-Arévalo, M Martín-Satué, J Blasi - Veterinary microbiology, 2012 - Elsevier
Epsilon toxin (ɛ-toxin), produced by Clostridium perfringens types B and D, causes fatal
enterotoxaemia in livestock. In the renal system, the toxin binds to target cells before
oligomerization, pore formation and cell death. Still, there is little information about the
cellular and molecular mechanism involved in the initial steps of the cytotoxic action of ɛ-
toxin, including the specific binding to the target sensitive cells. In the present report, the
binding step of ɛ-toxin to the MDCK cell line is characterized by means of an ELISA-based …
enterotoxaemia in livestock. In the renal system, the toxin binds to target cells before
oligomerization, pore formation and cell death. Still, there is little information about the
cellular and molecular mechanism involved in the initial steps of the cytotoxic action of ɛ-
toxin, including the specific binding to the target sensitive cells. In the present report, the
binding step of ɛ-toxin to the MDCK cell line is characterized by means of an ELISA-based …