Transgenic inhibition of Nogo-66 receptor function allows axonal sprouting and improved locomotion after spinal injury
S Li, JE Kim, S Budel, TG Hampton… - Molecular and Cellular …, 2005 - Elsevier
Axon growth after spinal injury is thought to be limited in part by myelin-derived proteins that
act via the Nogo-66 Receptor (NgR). To test this hypothesis, we sought to study recovery
from spinal cord injury (SCI) after inhibiting NgR transgenically with a soluble function-
blocking NgR fragment. Glial fibrillary acidic protein (gfap) gene regulatory elements were
used to generate mice that secrete NgR (310) ecto from astrocytes. After mid-thoracic dorsal
over-hemisection injury, gfap∷ ngr (310) ecto mice exhibit enhanced raphespinal and …
act via the Nogo-66 Receptor (NgR). To test this hypothesis, we sought to study recovery
from spinal cord injury (SCI) after inhibiting NgR transgenically with a soluble function-
blocking NgR fragment. Glial fibrillary acidic protein (gfap) gene regulatory elements were
used to generate mice that secrete NgR (310) ecto from astrocytes. After mid-thoracic dorsal
over-hemisection injury, gfap∷ ngr (310) ecto mice exhibit enhanced raphespinal and …