Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers
M Matsumoto, S Mariathasan, MH Nahm, F Baranyay… - Science, 1996 - science.org
M Matsumoto, S Mariathasan, MH Nahm, F Baranyay, JJ Peschon, DD Chaplin
Science, 1996•science.orgIn mice deficient in either lymphotoxin-α (LT-α) or the type I tumor necrosis factor (TNF)
receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral
lymphoid organs. Germinal center formation was restored in LT-α-deficient mice by
transplantation of normal bone marrow, indicating that the LT-α-expressing cells required to
establish this lymphoid structure are derived from bone marrow.
receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral
lymphoid organs. Germinal center formation was restored in LT-α-deficient mice by
transplantation of normal bone marrow, indicating that the LT-α-expressing cells required to
establish this lymphoid structure are derived from bone marrow.
In mice deficient in either lymphotoxin-α (LT-α) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-α-deficient mice by transplantation of normal bone marrow, indicating that the LT-α-expressing cells required to establish this lymphoid structure are derived from bone marrow.