Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease
MM Zeron, HB Fernandes, C Krebs, J Shehadeh… - Molecular and Cellular …, 2004 - Elsevier
Evidence suggests N-methyl-d-aspartate receptor (NMDAR) activation is involved in the
degeneration of striatal medium-sized spiny neurons (MSNs) in Huntington's disease (HD).
We tested the hypothesis that enhanced NMDAR-mediated excitotoxicity is mediated by the
mitochondrial-associated apoptotic pathway in cultured MSNs from YAC transgenic mice
expressing full-length huntingtin (htt) with a polyglutamine (polyQ) expansion of 46 or 72
(YAC46 or YAC72). NMDAR-mediated Ca2+ transients and mitochondrial membrane …
degeneration of striatal medium-sized spiny neurons (MSNs) in Huntington's disease (HD).
We tested the hypothesis that enhanced NMDAR-mediated excitotoxicity is mediated by the
mitochondrial-associated apoptotic pathway in cultured MSNs from YAC transgenic mice
expressing full-length huntingtin (htt) with a polyglutamine (polyQ) expansion of 46 or 72
(YAC46 or YAC72). NMDAR-mediated Ca2+ transients and mitochondrial membrane …