Nogo-C is sufficient to delay nerve regeneration
JE Kim, IE Bonilla, D Qiu, SM Strittmatter - Molecular and Cellular …, 2003 - Elsevier
Axonal regeneration succeeds in the peripheral but not central nervous system of adult
mammals. Peripheral clearance of myelin coupled with selective CNS expression of axon
growth inhibitors, such as Nogo, may account for this reparative disparity. To assess the
sufficiency of Nogo for limiting axonal regeneration, we generated transgenic mice
expressing Nogo-C in peripheral Schwann cells. Nogo-C includes the panisoform inhibitory
Nogo-66 domain, but not a second Nogo-A-specific inhibitory domain, allowing a selective …
mammals. Peripheral clearance of myelin coupled with selective CNS expression of axon
growth inhibitors, such as Nogo, may account for this reparative disparity. To assess the
sufficiency of Nogo for limiting axonal regeneration, we generated transgenic mice
expressing Nogo-C in peripheral Schwann cells. Nogo-C includes the panisoform inhibitory
Nogo-66 domain, but not a second Nogo-A-specific inhibitory domain, allowing a selective …