Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells
NR Mehta, PHH Lopez, AA Vyas, RL Schnaar - Journal of biological …, 2007 - ASBMB
In the injured nervous system, myelin-associated glycoprotein (MAG) on residual myelin
binds to receptors on axons, inhibits axon outgrowth, and limits functional recovery.
Conflicting reports identify gangliosides (GD1a and GT1b) and glycosylphosphatidylinositol-
anchored Nogo receptors (NgRs) as exclusive axonal receptors for MAG. We used enzymes
and pharmacological agents to distinguish the relative roles of gangliosides and NgRs in
MAG-mediated inhibition of neurite outgrowth from three nerve cell types, dorsal root …
binds to receptors on axons, inhibits axon outgrowth, and limits functional recovery.
Conflicting reports identify gangliosides (GD1a and GT1b) and glycosylphosphatidylinositol-
anchored Nogo receptors (NgRs) as exclusive axonal receptors for MAG. We used enzymes
and pharmacological agents to distinguish the relative roles of gangliosides and NgRs in
MAG-mediated inhibition of neurite outgrowth from three nerve cell types, dorsal root …