Executive dysfunction in early stages of Huntington's disease is associated with striatal and insular atrophy: a neuropsychological and voxel-based morphometric …
A Peinemann, S Schuller, C Pohl, T Jahn… - Journal of the …, 2005 - Elsevier
BACKGROUND: Huntington's disease (HD) is characterized by a progressive multisystem
neuronal atrophy in the brain. Apart from motor signs, cognitive symptoms, particularly
executive dysfunctions, are proposed to be recognizable in early stages of disease. The aim
of the present study was to clarify if cognitive dysfunction in early stages of HD is correlated
with loco-regional structural changes in 3D-MRI. METHODS: Twenty-five patients with
genetically confirmed HD in early clinical stages were included in the study and underwent …
neuronal atrophy in the brain. Apart from motor signs, cognitive symptoms, particularly
executive dysfunctions, are proposed to be recognizable in early stages of disease. The aim
of the present study was to clarify if cognitive dysfunction in early stages of HD is correlated
with loco-regional structural changes in 3D-MRI. METHODS: Twenty-five patients with
genetically confirmed HD in early clinical stages were included in the study and underwent …