Acute diarrhoeal diseases remain a leading cause of global morbidity and mortality particularly
among young children in resource-limited countries. Recent large studies utilizing case–…

Background Botswana has a well-developed antiretroviral therapy (ART) program that
serves as a regional model. With wide ART availability, the burden of advanced human …

Background. Botswana introduced monovalent G1P[8] rotavirus vaccine (RV1) in July 2012,
providing one of the first opportunities to assess the effectiveness of routine RV1 vaccination …

Objectives Although extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE)
and carbapenem-resistant Enterobacterales (CRE) are a global challenge, data on these …

Background CNS infections are a leading cause of HIV-related deaths in sub-Saharan Africa,
but causes and outcomes are poorly defined. We aimed to determine mortality and …

Two-hundred eighty matched bulk stool and anatomically designed flocked rectal swab
samples were collected from children admitted to the hospital with acute diarrhea in Botswana. …

Background. A monovalent human rotavirus vaccine (RV1) was introduced in Botswana in
July 2012. We assessed the impact of RV1 vaccination on childhood gastroenteritis-related …

Background The epidemiology of extended-spectrum cephalosporin-resistant Enterobacterales
(ESCrE) in low- and middle-income countries (LMICs) is poorly described. Identifying …

Bacterial blood stream infections (BSI) are a common cause of mortality and morbidity globally.
As the causative agents and the resulting treatment decisions vary, near-patient testing …

Background: Studies have demonstrated reduced rotavirus vaccine effectiveness (VE) in
resource-limited settings. Enteropathogen coinfections in rotavirus cases have been …