Acne is one of the most common disorders treated by dermatologists and other health care
providers. While it most often affects adolescents, it is not uncommon in adults and can also …

Zn 2+ is the second most prevalent trace element in the body and is present in particularly
large concentrations in the mammalian brain. Although Zn 2+ is a cofactor for many …

Mitochondria play a key role in determining cell fate during exposure to stress. Their role
during ischemia/reperfusion is particularly critical because of the conditions that promote …

Background Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and von
Willebrand factor, and it has an important role in platelet aggregation. It is known to be …

Lung cancer remains one of the leading causes of cancer-related death in developed
countries. Although lung adenocarcinomas with EGFR mutations or EML4-ALK fusions …

The Hill coefficient is commonly used to estimate the number of ligand molecules that are
required to bind to a receptor to produce a functional effect. However, for a receptor with …

Foxp3 activity is essential for the normal function of the immune system. Two types of
regulatory T (T reg) cells express Foxp3, thymus-generated natural T reg (nT reg) cells, and …

The hemodynamic determinants of the time-course of fall in isovolumic left ventricular
pressure were assessed in isolated canine left ventricular preparations. Pressure fall was …

Abstract Ever since Stephen Paget's 1889 hypothesis, metastatic organotropism has
remained one of cancer's greatest mysteries. Here we demonstrate that exosomes from …

Background Neoadjuvant chemotherapy and radiation followed by surgical resection of the
rectum is a standard treatment for locally advanced rectal cancer. A subset of rectal cancer is …