Introduction Breast cancer remains a significant scientific, clinical and societal challenge.
This gap analysis has reviewed and critically assessed enduring issues and new challenges …

Estrogen is essential for normal growth and differentiation in the mammary gland. It also
supports growth of approximately 50% of primary breast cancers. For this reason, removal of …

Importance SARS-CoV-2 infection has been associated with more severe disease and
death in patients with cancer. However, the implications of certain tumor types, treatments …

On 24 th November 2021, the sequence of a new SARS-CoV-2 viral isolate Omicron-B. 1.1.
529 was announced, containing far more mutations in Spike (S) than previously reported …

Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of
breast cancers and its target genes dictate cell growth and endocrine response, yet genomic …

Background It is unclear whether radial compared with femoral access improves outcomes
in unselected patients with acute coronary syndromes undergoing invasive management …

Background Microbiological characterisation of co-infections and secondary infections in
patients with COVID-19 is lacking, and antimicrobial use is high. We aimed to describe …

There is a pressing need for more effective appetite-stimulatory therapies for many patient
groups including those with cancer. We have previously demonstrated that the gastric …

Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral
to metastasis (eg, proliferation, motility, secretion, and invasion), although their contribution …

Estrogen receptor-α (ER) is the driving transcription factor in most breast cancers, and its
associated proteins can influence drug response, but direct methods for identifying …