User profiles for "author:Pachter L"
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Museum of spatial transcriptomics
The function of many biological systems, such as embryos, liver lobules, intestinal villi, and
tumors, depends on the spatial organization of their cells. In the past decade, high …
tumors, depends on the spatial organization of their cells. In the past decade, high …
The health of Latino children: urgent priorities, unanswered questions, and a research agenda
G Flores, E Fuentes-Afflick, O Barbot, O Carter-Pokras… - Jama, 2002 - jamanetwork.com
Latinos recently became the largest racial/ethnic minority group of US children. The Latino
Consortium of the American Academy of Pediatrics Center for Child Health Research …
Consortium of the American Academy of Pediatrics Center for Child Health Research …
Colonic anastomotic leak: risk factors, diagnosis, and treatment
PT Kingham, LH Pachter - Journal of the American College of …, 2009 - journals.lww.com
Anastomotic dehiscence is one of the most dreaded complications of operations of the large
intestine. Breakdown of an anastomosis results in increased morbidity and mortality and …
intestine. Breakdown of an anastomosis results in increased morbidity and mortality and …
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
Recent advances in high-throughput cDNA sequencing (RNA-seq) can reveal new genes
and splice variants and quantify expression genome-wide in a single assay. The volume …
and splice variants and quantify expression genome-wide in a single assay. The volume …
The ENCODE (ENCyclopedia of DNA elements) project
EA Feingold, PJ Good, MS Guyer, S Kamholz… - Science, 2004 - scholarworks.bwise.kr
The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional
elements in the human genome sequence. The pilot phase of the Project is focused on a …
elements in the human genome sequence. The pilot phase of the Project is focused on a …
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
Management Group Liefer Laura A. 51 Wetterstrand … - nature, 2007 - nature.com
We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
High-throughput mRNA sequencing (RNA-Seq) promises simultaneous transcript discovery
and abundance estimation,,. However, this would require algorithms that are not restricted …
and abundance estimation,,. However, this would require algorithms that are not restricted …
TopHat: discovering splice junctions with RNA-Seq
Motivation: A new protocol for sequencing the messenger RNA in a cell, known as RNA-
Seq, generates millions of short sequence fragments in a single run. These fragments, or …
Seq, generates millions of short sequence fragments in a single run. These fragments, or …
Near-optimal probabilistic RNA-seq quantification
We present kallisto, an RNA-seq quantification program that is two orders of magnitude
faster than previous approaches and achieves similar accuracy. Kallisto pseudoaligns reads …
faster than previous approaches and achieves similar accuracy. Kallisto pseudoaligns reads …
Differential analysis of gene regulation at transcript resolution with RNA-seq
Differential analysis of gene and transcript expression using high-throughput RNA
sequencing (RNA-seq) is complicated by several sources of measurement variability and …
sequencing (RNA-seq) is complicated by several sources of measurement variability and …