Optimized tools for multicolor stochastic labeling reveal diverse stereotyped cell arrangements in the fly visual system

A Nern, BD Pfeiffer, GM Rubin - Proceedings of the …, 2015 - National Acad Sciences
We describe the development and application of methods for high-throughput
neuroanatomy in Drosophila using light microscopy. These tools enable efficient multicolor …

A visual motion detection circuit suggested by Drosophila connectomics

S Takemura, A Bharioke, Z Lu, A Nern, S Vitaladevuni… - Nature, 2013 - nature.com
Animal behaviour arises from computations in neuronal circuits, but our understanding of
these computations has been frustrated by the lack of detailed synaptic connection maps, or …

A Cdc24p-Far1p-Gβγ protein complex required for yeast orientation during mating

A Nern, RA Arkowitz - The Journal of cell biology, 1999 - rupress.org
Oriented cell growth requires the specification of a site for polarized growth and subsequent
orientation of the cytoskeleton towards this site. During mating, haploid Saccharomyces …

The connectome of the adult Drosophila mushroom body provides insights into function

F Li, JW Lindsey, EC Marin, N Otto, M Dreher… - Elife, 2020 - elifesciences.org
Making inferences about the computations performed by neuronal circuits from synapse-
level connectivity maps is an emerging opportunity in neuroscience. The mushroom body …

A directional tuning map of Drosophila elementary motion detectors

MS Maisak, J Haag, G Ammer, E Serbe, M Meier… - Nature, 2013 - nature.com
The extraction of directional motion information from changing retinal images is one of the
earliest and most important processing steps in any visual system. In the fly optic lobe, two …

Multiple new site-specific recombinases for use in manipulating animal genomes

A Nern, BD Pfeiffer, K Svoboda… - Proceedings of the …, 2011 - National Acad Sciences
Site-specific recombinases have been used for two decades to manipulate the structure of
animal genomes in highly predictable ways and have become major research tools …

[PDF][PDF] Neuronal circuits integrating visual motion information in Drosophila melanogaster

K Shinomiya, A Nern, IA Meinertzhagen, SM Plaza… - Current Biology, 2022 - cell.com
The detection of visual motion enables sophisticated animal navigation, and studies on flies
have provided profound insights into the cellular and circuit bases of this neural …

A GTP-exchange factor required for cell orientation

A Nern, RA Arkowitz - Nature, 1998 - nature.com
Abstract The Rho-family of GTPases and their regulators are essential for cytoskeletal
reorganization and transcriptional activation in response to extracellular signals,. Little is …

BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets

L Manubens-Gil, Z Zhou, H Chen, A Ramanathan… - Nature …, 2023 - nature.com
BigNeuron is an open community bench-testing platform with the goal of setting open
standards for accurate and fast automatic neuron tracing. We gathered a diverse set of …

Visual projection neurons in the Drosophila lobula link feature detection to distinct behavioral programs

M Wu, A Nern, WR Williamson, MM Morimoto… - Elife, 2016 - elifesciences.org
Visual projection neurons (VPNs) provide an anatomical connection between early visual
processing and higher brain regions. Here we characterize lobula columnar (LC) cells, a …