The vast majority of the adult fly ventral nerve cord is composed of 34 hemilineages, which
are clusters of lineally related neurons. Neurons in these hemilineages use one of the three …

During sensory organ precursor (SOP) specification, a single cell is selected from a
proneural cluster of cells. Here, we present evidence that Senseless (Sens), a zinc-finger …

Neurogenesis in Drosophila occurs in two phases, embryonic and post-embryonic, in which
the same set of neuroblasts give rise to the distinct larval and adult nervous systems …

NeuromedinU is a potent regulator of food intake and activity in mammals. In Drosophila,
neurons producing the homologous neuropeptide hugin regulate feeding and locomotion in …

Cell-type-specific tools facilitate the identification and functional characterization of the
distinct cell types that form the complexity of neuronal circuits. A large collection of existing …

The extracellular matrix (ECM) regulates cell migration and sculpts organ shape. AdamTS
proteins are extracellular metalloproteases known to modify ECM proteins and promote cell …

Glucose is arguably the most important molecule in metabolism, and its dysregulation
underlies diabetes. We describe a family of single-wavelength genetically encoded glucose …

Insulin signaling plays a pivotal role in metabolic control and aging, and insulin accordingly
is a key factor in several human diseases. Despite this importance, the in vivo activity …

The Drosophila ventral nerve cord (VNC) is composed of thousands of neurons born from a
set of individually identifiable stem cells. The VNC harbors neuronal circuits required to …

Individual neurons adopt and maintain defined morphological and physiological phenotypes
as a result of the expression of specific combinations of transcription factors. In particular …