Chemical modifications to DNA and histone proteins form a complex regulatory network that
modulates chromatin structure and genome function. The epigenome refers to the complete …

Systematic studies of the cancer genome have exploded in recent years. These studies
have revealed scores of new cancer genes, including many in processes not previously …

Human disease genes show enormous variation in their allelic spectra; that is, in the number
and population frequency of the disease-predisposing alleles at the loci. For some genes …

There is growing recognition that mammalian cells produce many thousands of large
intergenic transcripts,,,. However, the functional significance of these transcripts has been …

The advent of complete genetic linkage maps consisting of codominant DNA markers
[typically restriction fragment length polymorphisms (RFLPs)] has stimulated interest in the …

The most highly conserved noncoding elements (HCNEs) in mammalian genomes cluster
within regions enriched for genes encoding developmentally important transcription factors …

We recently showed that the mammalian genome encodes> 1,000 large intergenic
noncoding (linc) RNAs that are clearly conserved across mammals and, thus, functional …

Although thousands of large intergenic non-coding RNAs (lincRNAs) have been identified in
mammals, few have been functionally characterized, leading to debate about their biological …

Insulin resistance is a cardinal feature of type 2 diabetes and is characteristic of a wide
range of other clinical and experimental settings. Little is known about why insulin resistance …

We describe Hi-C, a method that probes the three-dimensional architecture of whole
genomes by coupling proximity-based ligation with massively parallel sequencing. We …