Identifying the genomic regions bound by sequence-specific regulatory factors is central
both to deciphering the complex DNA cis-regulatory code that controls transcription in …

Background We previously established that six sequence-specific transcription factors that
initiate anterior/posterior patterning in Drosophila bind to overlapping sets of thousands of …

To fully understand animal transcription networks, it is essential to accurately measure the
spatial and temporal expression patterns of transcription factors and their targets. We …

Background To model and thoroughly understand animal transcription networks, it is
essential to derive accurate spatial and temporal descriptions of developing gene …

Background To accurately describe gene expression and computationally model animal
transcriptional networks, it is essential to determine the changing locations of cells in …

The organization of nuclear proteins is linked to cell and tissue phenotypes. When cells
arrest proliferation, undergo apoptosis, or differentiate, distribution of nuclear proteins …

Budding and vesiculation of erythrocyte membranes occurs by a process involving an
uncoupling of the membrane skeleton from the lipid bilayer. Vesicle formation provides an …

The remodeling of nuclear organization during differentiation and the dramatic alteration of
nuclear organization associated with cancer development are well documented. However …

The ability of transmembrane receptor proteins to change their association with the
cytoskeleton in response to ligand binding seems to be a key mechanism of signal …

To allow a more rigorous understanding of animal gene regulatory networks, the Berkeley
Drosophila Transcription Network Project (BDTNP) has developed a suite of methods that …