Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years,
increased understanding of the mechanism of action of 5-FU has led to the development of …

Resistance to chemotherapy and molecularly targeted therapies is a major problem facing
current cancer research. The mechanisms of resistance to'classical'cytotoxic …

Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease.
Both represent chronic inflammation of the gastrointestinal tract, which displays …

Six DNA regions were evaluated as potential DNA barcodes for Fungi, the second largest
kingdom of eukaryotic life, by a multinational, multilaboratory consortium. The region of the …

Background—Cardiosphere-derived cells (CDCs) isolated from human endomyocardial
biopsies reduce infarct size and improve cardiac function in mice. Safety and efficacy testing …

Thymidylate synthase (TS) is the target enzyme for 5-fluorouracil (5-FU). We have correlated
TS protein and gene expression with the response in patients with colorectal (n= 9) and …

Context Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic
cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies are possible; …

Resistance to chemotherapy limits the effectiveness of anti‐cancer drug treatment. Tumours
may be intrinsically drug‐resistant or develop resistance to chemotherapy during treatment …

This study looks at blood flow through four different right coronary arteries, which have been
reconstructed from bi-plane angiograms. Five non-Newtonian blood models, as well as the …

The limit of the Colletotrichum gloeosporioides species complex is defined genetically,
based on a strongly supported clade within the Colletotrichum ITS gene tree. All taxa …