The specification of dorsal cell fates in the vertebrate central nervous system

KJ Lee, TM Jessell - Annual review of neuroscience, 1999 - annualreviews.org
▪ Abstract The generation of distinct classes of neurons at defined positions within the
developing vertebrate nervous system depends on inductive signals provided by local cell …

Diversity and pattern in the developing spinal cord

Y Tanabe, TM Jessell - Science, 1996 - science.org
The generation of distinct neuronal cell types in appropriate numbers and at precise
positions underlies the assembly of neural circuits that encode animal behavior. Despite the …

Neuronal specification in the spinal cord: inductive signals and transcriptional codes

TM Jessell - Nature Reviews Genetics, 2000 - nature.com
Neural circuits are assembled with remarkable precision during embryonic development,
and the selectivity inherent in their formation helps to define the behavioural repertoire of the …

Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm

KF Liem Jr, G Tremml, H Roelink, TM Jessell - Cell, 1995 - cell.com
The cellular interactions that control the differentiation of dorsal cell types from neural
progenitors have been examined in neural plate explants. Certain genes that are expressed …

Opiate analgesics inhibit substance P release from rat trigeminal nucleus

TM Jessell, LL Iversen - Nature, 1977 - nature.com
Abstract THE undecapeptide substance P (SP) may act as a transmitter released from the
terminals of primary sensory nerves in the spinal cord1–2. SP has been shown to be highly …

[HTML][HTML] Directed differentiation of embryonic stem cells into motor neurons

H Wichterle, I Lieberam, JA Porter, TM Jessell - Cell, 2002 - cell.com
Inductive signals and transcription factors involved in motor neuron generation have been
identified, raising the question of whether these developmental insights can be used to …

[HTML][HTML] A role for the roof plate and its resident TGFβ-related proteins in neuronal patterning in the dorsal spinal cord

KF Liem, G Tremml, TM Jessell - Cell, 1997 - cell.com
Distinct neuronal cell types are generated at characteristic times and positions in the dorsal
horn of the spinal cord. We provide evidence that the identity and pattern of generation of …

Chemotropic guidance of developing axons in the mammalian central nervous system

M Tessier-Lavigne, M Placzek, AGS Lumsden, J Dodd… - Nature, 1988 - nature.com
In the developing nervous system, axons project considerable distances along stereotyped
pathways to reach their targets. Axon guidance depends partly on the recognition of cell …

Skilled reaching relies on a V2a propriospinal internal copy circuit

E Azim, J Jiang, B Alstermark, TM Jessell - Nature, 2014 - nature.com
The precision of skilled forelimb movement has long been presumed to rely on rapid
feedback corrections triggered by internally directed copies of outgoing motor commands …

Molecular characterization of a functional cDNA encoding the serotonin 1c receptor

D Julius, AB MacDermott, R Axel, TM Jessell - Science, 1988 - science.org
Neurons that release serotonin as a neurotransmitter project to most regions of the central
and peripheral nervous system and mediate diverse neural functions. The physiological …