Drosophila melanogaster is one of the most well studied genetic model organisms;
nonetheless, its genome still contains unannotated coding and non-coding genes …

We demonstrate the feasibility of generating thousands of transgenic Drosophila
melanogaster lines in which the expression of an exogenous gene is reproducibly directed …

Animal transcriptomes are dynamic, with each cell type, tissue and organ system expressing
an ensemble of transcript isoforms that give rise to substantial diversity. Here we have …

Background Site-specific transcription factors (TFs) bind DNA regulatory elements to control
expression of target genes, forming the core of gene regulatory networks. Despite decades …

The transcriptome is the readout of the genome. Identifying common features in it across
distant species can reveal fundamental principles. To this end, the ENCODE and …

Background The development of complex organisms is believed to involve progressive
restrictions in cellular fate. Understanding the scope and features of chromatin dynamics …

The mod el organism E ncylopedia of R egulatory Elements (modERN) project was
designed to generate genome-wide binding profiles for the majority of transcription... To …

Spatial gene expression patterns enable the detection of local covariability and are
extremely useful for identifying local gene interactions during normal development. The …

In animals, each sequence-specific transcription factor typically binds to thousands of
genomic regions in vivo. Our previous studies of 20 transcription factors show that most …

Matrix assisted laser desorption/ionization imaging has greatly improved our understanding
of spatial biology, however a robust bioinformatic pipeline for data analysis is lacking. Here …