User profiles for "author:Guttman M"
 | Mitchell GuttmanProfessor of Biology, California Institute of Technology Verified email at lncrna.caltech.edu Cited by 52173 |
Modular regulatory principles of large non-coding RNAs
It is clear that RNA has a diverse set of functions and is more than just a messenger between
gene and protein. The mammalian genome is extensively transcribed, giving rise to …
gene and protein. The mammalian genome is extensively transcribed, giving rise to …
Long non-coding RNAs: definitions, functions, challenges and recommendations
Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
of complex organisms. The term 'lncRNAs' encompasses RNA polymerase I (Pol I), Pol II …
Computational methods for transcriptome annotation and quantification using RNA-seq
High-throughput RNA sequencing (RNA-seq) promises a comprehensive picture of the
transcriptome, allowing for the complete annotation and quantification of all genes and their …
transcriptome, allowing for the complete annotation and quantification of all genes and their …
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
There is growing recognition that mammalian cells produce many thousands of large
intergenic transcripts,,,. However, the functional significance of these transcripts has been …
intergenic transcripts,,,. However, the functional significance of these transcripts has been …
lincRNAs act in the circuitry controlling pluripotency and differentiation
Although thousands of large intergenic non-coding RNAs (lincRNAs) have been identified in
mammals, few have been functionally characterized, leading to debate about their biological …
mammals, few have been functionally characterized, leading to debate about their biological …
Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs
Massively parallel cDNA sequencing (RNA-Seq) provides an unbiased way to study a
transcriptome, including both coding and noncoding genes. Until now, most RNA-Seq …
transcriptome, including both coding and noncoding genes. Until now, most RNA-Seq …
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3
Many long non-coding RNAs (lncRNAs) affect gene expression, but the mechanisms by
which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is …
which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is …
[HTML][HTML] A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response
Recently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported.
These RNAs are evolutionarily conserved in mammalian genomes and thus presumably …
These RNAs are evolutionarily conserved in mammalian genomes and thus presumably …
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
We recently showed that the mammalian genome encodes> 1,000 large intergenic
noncoding (linc) RNAs that are clearly conserved across mammals and, thus, functional …
noncoding (linc) RNAs that are clearly conserved across mammals and, thus, functional …
[HTML][HTML] Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins
Large noncoding RNAs are emerging as an important component in cellular regulation.
Considerable evidence indicates that these transcripts act directly as functional RNAs rather …
Considerable evidence indicates that these transcripts act directly as functional RNAs rather …