The invertebrate Drosophila melanogaster has been a powerful model for understanding
blood cell development and immunity. Drosophila is a holometabolous insect, which …

Fish, mice, and humans rely on two coexisting myeloid blood cell systems. One is sustained
by hematopoietic progenitor cells, which reside in specialized microenvironments (niches) in …

Cell-type-specific transcriptional profiling often requires the isolation of specific cell types
from complex tissues. We have developed" TaDa," a technique that enables cell-specific …

Stem cells proliferate through symmetric division or self-renew through asymmetric division
whilst generating differentiating cell types. The balance between symmetric and asymmetric …

The proper balance between symmetric and asymmetric stem cell division is crucial both to
maintain a population of stem cells and to prevent tumorous overgrowth. Neural stem cells in …

The use of adult Drosophila melanogaster as a model for hematopoiesis or organismal
immunity has been debated. Addressing this question, we identify an extensive reservoir of …

Background During early brain development, the organisation of neural progenitors into a
neuroepithelial sheet maintains tissue integrity during growth. Neuroepithelial cohesion and …

An outstanding question in animal development, tissue homeostasis and disease is how cell
populations adapt to sensory inputs. During Drosophila larval development, hematopoietic …

Abstract The CD56 antigen (NCAM-1) is highly expressed on several malignancies with
neuronal or neuroendocrine differentiation, including small-cell lung cancer and …

Background Neural stem cells generate all of the neurons and glial cells in the central
nervous system, both during development and in the adult to maintain homeostasis. In the …