Peroxisome proliferator–activated receptors (PPARs) regulate energy metabolism and
hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non …

Chromatin is a well-known obstacle to transcription as it controls DNA accessibility, which
directly impacts the recruitment of the transcriptional machinery. The recent burst of …

The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and
the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA …

Abstract We present Model-based Analysis of ChIP-Seq data, MACS, which analyzes data
generated by short read sequencers such as Solexa's Genome Analyzer. MACS empirically …

Estrogen plays an essential physiologic role in reproduction and a pathologic one in breast
cancer. The completion of the human genome has allowed the identification of the …

Complex organisms require tissue-specific transcriptional programs, yet little is known about
how these are established. The transcription factor FoxA1 is thought to contribute to gene …

The transcription factor GATA-3 is required for normal mammary gland development, and its
expression is highly correlated with estrogen receptor α (ERα) in human breast tumors …

Estrogen stimulates the proliferation of the most common type of human breast cancer that
expresses estrogen receptor α (ERα) through the activation of the cyclin D1 (CCND1) …

Hepatocyte Nuclear Factor 4 (HNF4) is a transcription factor (TF) belonging to the nuclear
receptor family whose expression and activities are restricted to a limited number of organs …

Genome-wide association studies (GWAS) have identified thousands of SNPs that are
associated with human traits and diseases. But, because the vast majority of these SNPs are …