Neural progenitors generate distinct cell types at different stages, but the mechanisms
controlling these temporal transitions are poorly understood. In the Drosophila CNS, a …

The Drosophila homologue of the epidermal growth factor receptor (DEGFr or DER, also
called torpedo or top) has many mutant alleles that cause either embryonic lethality (both …

In Drosophila, neural stem cells or neuroblasts (NBs) acquire different identities according to
their site of origin in the embryonic neuroectoderm. Their identity determines the number of …

One of the key aspects of functional nervous systems is the restriction of particular neural
subtypes to specific regions, which permits the establishment of differential segment-specific …

Three main events characterize the development of the proximal-distal axis of the
Drosophila wing disc: first, generation of nested circular domains defined by different …

The Drosophila gene wingless encodes a secreted signalling molecule that is required for
many patterning events in both embryonic and postembryonic development. In the wing …

Nab proteins form an evolutionarily conserved family of transcriptional co-regulators
implicated in multiple developmental events in various organisms. They lack DNA-binding …

Identification of the genetic mechanisms underlying the specification of large numbers of
different neuronal cell fates from limited numbers of progenitor cells is at the forefront of …

During the development of the central nervous system, neural progenitors generate an
enormous number of distinct types of neuron and glial cells by asymmetric division. Intrinsic …

Although the Hox genes are the main factors involved in the generation of diversity along the
anterior/posterior body axis of segmented organisms, it is still largely unknown how these …