Stem cells are captivating because they have the potential to make multiple cell types yet
maintain their undifferentiated state. Recent studies of Drosophila and mammalian neural …

The vast diversity of neurons and glia of the CNS is generated from a small, heterogeneous
population of progenitors that undergo transcriptional changes during development to …

A small pool of neural progenitors generates the vast diversity of cell types in the CNS.
Spatial patterning specifies progenitor identity, followed by temporal patterning within …

Neural precursors often generate distinct cell types in a specific order, but the intrinsic or
extrinsic cues regulating the timing of cell fate specification are poorly understood. Here we …

The molecular mechanisms used to generate neuronal diversity are largely unknown. To
identify genes controlling cell fate in the Drosophila central nervous system, we screened for …

The first step in generating cellular diversity in the Drosophila central nervous system is the
formation of a segmentally reiterated array of neural precursor cells, called neuroblasts …

Mammalian neural stem cells generate transit amplifying progenitors that expand the
neuronal population, but these type of progenitors have not been studied in Drosophila. The …

An experimental analysis of neurogenesis requires a detailed understanding of wild-type
neural development. Recent DiI cell lineage studies have begun to elucidate the family of …

Both intrinsic and extrinsic factors are known to regulate sibling cell fate. Here we describe a
novel mechanism for the asymmetric localization of a transcription factor to one daughter cell …

Asymmetric cell divisions play a key role in establishing neuronal diversity in the mammalian
and Drosophila CNS, but the mechanisms involved are mostly unknown. The Drosophila …