Although fungal infections contribute substantially to human morbidity and mortality, the
impact of these diseases on human health is not widely appreciated. Moreover, despite the …

▪ Abstract Macrophages express a broad range of plasma membrane receptors that mediate
their interactions with natural and altered-self components of the host as well as a range of …

Dectin-1 is a natural killer (NK)-cell-receptor-like C-type lectin that is thought to be involved
in innate immune responses to fungal pathogens. This transmembrane signalling receptor …

Zymosan is a β-glucan–and mannan-rich particle that is widely used as a cellular activator
for examining the numerous responses effected by phagocytes. The macrophage mannose …

The carbohydrate polymers known as β-1, 3-d-glucans exert potent effects on the immune
system—stimulating antitumour and antimicrobial activity, for example—by binding to …

The ability of fungal-derived β-glucan particles to induce leukocyte activation and the
production of inflammatory mediators, such as tumor necrosis factor (TNF)-α, is a well …

Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of
breast cancers and its target genes dictate cell growth and endocrine response, yet genomic …

Fungal diseases have emerged as significant causes of morbidity and mortality, particularly
in immune-compromised individuals, prompting greater interest in understanding the …

The C-type lectin dectin-1 binds to yeast and signals through the kinase Syk and the adaptor
CARD9 to induce production of interleukin 10 (IL-10) and IL-2 in dendritic cells (DCs) …

Abstract β-Glucan is one of the most abundant polysaccharides in fungal pathogens, yet its
importance in antifungal immunity is unclear. Here we show that deficiency of dectin-1, the …