Stem cells have the remarkable ability to give rise to both self-renewing and differentiating
daughter cells. Drosophila neural stem cells segregate cell-fate determinants from the self …

Central nervous system development inDrosophilastarts with the delamination from the
neuroectoderm of about 30 neuroblasts (NBs) per hemisegment. Understanding the …

InDrosophila, central nervous system (CNS) formation starts with the delamination from the
neuroectoderm of about 30 neuroblasts (NBs) per hemisegment. They give rise to …

We have used a retrograde labeling technique to identify motorneurons for each of the 30
body wall muscles of an abdominal hemisegment in the late stage 16 Drosophila embryo …

Drosophila is an ideal system for identifying genes that control central nervous system
(CNS) development. Particularly useful tools include molecular markers for subsets of neural …

It has been hypothesised that tau protein, when hyper-phosphorylated as in Alzheimer's
disease (AD), does not bind effectively to microtubules and is no longer able to stabilise …

We present a new method for marking single cells and tracing their development through
embryogenesis. Cells are labelled with a lipophilic fluorescent tracer (DiI) in their normal …

The Drosophila ventral nerve cord (vNC) derives from a stereotyped population of neural
stem cells, neuroblasts (NBs), each of which gives rise to a characteristic cell lineage. The …

Tau exists as six closely related protein isoforms in the adult human brain. These are
generated from alternative splicing of a single mRNA transcript and they differ in the …

Stem cells control their mitotic activity to decide whether to proliferate or to stay in
quiescence. Drosophila neural stem cells (NSCs) are quiescent at early larval stages, when …