Pioneer factors as master regulators of the epigenome and cell fate
A Balsalobre, J Drouin - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …
Clock genes in mammalian peripheral tissues
A Balsalobre - Cell and tissue research, 2002 - Springer
For many years, neurons of the suprachiasmatic nucleus (SCN) in the hypothalamus were
thought to contain the unique mammalian clock controlling circadian rhythmicity of …
thought to contain the unique mammalian clock controlling circadian rhythmicity of …
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
A Balsalobre, SA Brown, L Marcacci, F Tronche… - Science, 2000 - science.org
In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the
brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we …
brain, which harbors the central pacemaker, but also in most peripheral tissues. Here, we …
[HTML][HTML] A serum shock induces circadian gene expression in mammalian tissue culture cells
A Balsalobre, F Damiola, U Schibler - Cell, 1998 - cell.com
The treatment of cultured rat-1 fibroblasts or H35 hepatoma cells with high concentrations of
serum induces the circadian expression of various genes whose transcription also oscillates …
serum induces the circadian expression of various genes whose transcription also oscillates …
[PDF][PDF] Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts
A Balsalobre, L Marcacci, U Schibler - Current Biology, 2000 - cell.com
In mammals, all overt circadian rhythms are thought to be coordinated by a central
pacemaker residing in the hypothalamic suprachiasmatic nucleus (SCN)[1]. The phase of …
pacemaker residing in the hypothalamic suprachiasmatic nucleus (SCN)[1]. The phase of …
[HTML][HTML] The Stat3/GR interaction code: predictive value of direct/indirect DNA recruitment for transcription outcome
D Langlais, C Couture, A Balsalobre, J Drouin - Molecular cell, 2012 - cell.com
Transcription factor recruitment to genomic sites of action is primarily due to direct protein:
DNA interactions. The subsequent recruitment of coregulatory complexes leads to either …
DNA interactions. The subsequent recruitment of coregulatory complexes leads to either …
Pioneer factor Pax7 deploys a stable enhancer repertoire for specification of cell fate
Pioneer transcription factors establish new cell-fate competence by triggering chromatin
remodeling. However, many features of pioneer action, such as their kinetics and stability …
remodeling. However, many features of pioneer action, such as their kinetics and stability …
The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling
L Budry, A Balsalobre, Y Gauthier… - Genes & …, 2012 - genesdev.cshlp.org
The anterior and intermediate lobes of the pituitary gland derive from the surface ectoderm.
They provide a simple system to assess mechanisms of developmental identity established …
They provide a simple system to assess mechanisms of developmental identity established …
Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening
A Mayran, K Sochodolsky, K Khetchoumian… - Nature …, 2019 - nature.com
Pioneer transcription factors are characterized by having the unique property of enabling the
opening of closed chromatin sites, for implementation of cell fates. We previously found that …
opening of closed chromatin sites, for implementation of cell fates. We previously found that …
Mutations in NFKB2and potential genetic heterogeneity in patients with DAVID syndrome, having variable endocrine and immune deficiencies
T Brue, MH Quentien, K Khetchoumian, M Bensa… - BMC medical …, 2014 - Springer
Background DAVID syndrome is a rare condition combining anterior pituitary hormone
deficiency with common variable immunodeficiency. NFKB2 mutations have recently been …
deficiency with common variable immunodeficiency. NFKB2 mutations have recently been …