Mitophagy is an evolutionarily conserved process involving the autophagic targeting and
clearance of mitochondria destined for removal. Recent insights into the complex nature of …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Existing therapeutic strategies for managing Parkinson disease (PD), which focus on
addressing the loss of dopamine and dopaminergic function linked with degeneration of …

Our understanding of the process of autophagy and its role in health and diseases has
grown remarkably in the last two decades. Early work established autophagy as a general …

It has been 200 years since Parkinson disease (PD) was described by Dr. Parkinson in
1817. The disease is the second most common neurodegenerative disease characterized …

The central functions fulfilled by mitochondria as both energy generators essential for tissue
homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight …

Maintenance of a healthy proteome is essential for cellular homeostasis and loss of
proteostasis is associated with tissue dysfunction and neurodegenerative disease. The …

Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and
oxidative stress, which are important factors contributing to the development of brain …

Prolonging the healthy life span and limiting neurological illness are imperative goals in
gerontology. Age-related neurodegeneration is progressive and leads to severe diseases …

An essential advantage during eukaryotic cell evolution was the acquisition of a network of
mitochondria as a source of energy for cell metabolism and contrary to conventional …