The molecular landscape of head and neck cancer
CR Leemans, PJF Snijders, RH Brakenhoff - Nature Reviews Cancer, 2018 - nature.com
Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the
upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk …
upper aerodigestive tract and are unexpectedly heterogeneous in nature. Classical risk …
[HTML][HTML] Mechanisms of temozolomide resistance in glioblastoma-a comprehensive review
N Singh, A Miner, L Hennis, S Mittal - Cancer drug resistance, 2021 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults and has an
exceedingly low median overall survival of only 15 months. Current standard-of-care for …
exceedingly low median overall survival of only 15 months. Current standard-of-care for …
Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning
Visual inspection of histopathology slides is one of the main methods used by pathologists
to assess the stage, type and subtype of lung tumors. Adenocarcinoma (LUAD) and …
to assess the stage, type and subtype of lung tumors. Adenocarcinoma (LUAD) and …
[HTML][HTML] Comprehensive genomic characterization of head and neck squamous cell carcinomas
Cancer Genome Atlas Network - Nature, 2015 - ncbi.nlm.nih.gov
Abstract The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas
(HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we …
(HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we …
Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis
I Pastushenko, F Mauri, Y Song, F de Cock, B Meeusen… - Nature, 2021 - nature.com
FAT1, which encodes a protocadherin, is one of the most frequently mutated genes in
human cancers,,,–. However, the role and the molecular mechanisms by which FAT1 …
human cancers,,,–. However, the role and the molecular mechanisms by which FAT1 …
High burden and pervasive positive selection of somatic mutations in normal human skin
How somatic mutations accumulate in normal cells is central to understanding cancer
development but is poorly understood. We performed ultradeep sequencing of 74 cancer …
development but is poorly understood. We performed ultradeep sequencing of 74 cancer …
Gastric adenocarcinoma
JA Ajani, J Lee, T Sano, YY Janjigian, D Fan… - Nature reviews Disease …, 2017 - nature.com
Gastric cancers, with gastric adenocarcinoma (GAC) as the most common histological type,
impose a considerable global health burden. Although the screening strategies for early …
impose a considerable global health burden. Although the screening strategies for early …
Wnt and PI3K/Akt/mTOR survival pathways as therapeutic targets in glioblastoma
A Barzegar Behrooz, Z Talaie, F Jusheghani… - International journal of …, 2022 - mdpi.com
Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …
Loss of the FAT1 tumor suppressor promotes resistance to CDK4/6 inhibitors via the hippo pathway
Summary Cyclin dependent kinase 4/6 (CDK4/6) inhibitors (CDK4/6i) are effective in breast
cancer; however, drug resistance is frequently encountered and poorly understood. We …
cancer; however, drug resistance is frequently encountered and poorly understood. We …
Circadian rhythm-related genes index: A predictor for HNSCC prognosis, immunotherapy efficacy, and chemosensitivity
H Chi, J Yang, G Peng, J Zhang, G Song, X Xie… - Frontiers in …, 2023 - frontiersin.org
Background Head and neck squamous cell carcinoma (HNSCC) is the most common head
and neck cancer and is highly aggressive and heterogeneous, leading to variable prognosis …
and neck cancer and is highly aggressive and heterogeneous, leading to variable prognosis …