Natural products have played a critical role in medicine due to their ability to bind and
modulate cellular targets involved in disease. Medicinal plants hold a variety of bioactive …

The extracellular matrix (ECM) is a fundamental component of multicellular organisms that
provides mechanical and chemical cues that orchestrate cellular and tissue organization …

The UniProt knowledgebase is a large resource of protein sequences and associated
detailed annotation. The database contains over 60 million sequences, of which over half a …

In the last two years the Pfam database (http://pfam. xfam. org) has undergone a substantial
reorganisation to reduce the effort involved in making a release, thereby permitting more …

PD-1 immune checkpoint blockade provides significant clinical benefits for melanoma
patients. We analyzed the somatic mutanomes and transcriptomes of pretreatment …

Abstract The PANTHER database (Protein ANalysis THrough Evolutionary Relationships,
http://pantherdb. org) contains comprehensive information on the evolution and function of …

Abstract SWISS-MODEL Repository (SMR) is a database of annotated 3D protein structure
models generated by the automated SWISS-MODEL homology modeling pipeline. It …

Abstract The Gene Ontology (GO) is a comprehensive resource of computable knowledge
regarding the functions of genes and gene products. As such, it is extensively used by the …

Abstract InterPro (http://www. ebi. ac. uk/interpro/) is a freely available database used to
classify protein sequences into families and to predict the presence of important domains …

There is increasing interest in employing shotgun sequencing, rather than amplicon
sequencing, to analyze microbiome samples. Typical projects may involve hundreds of …