Rosace: a robust deep mutational scanning analysis framework employing position and mean-variance shrinkage
Deep mutational scanning (DMS) measures the effects of thousands of genetic variants in a
protein simultaneously. The small sample size renders classical statistical methods …
protein simultaneously. The small sample size renders classical statistical methods …
[HTML][HTML] Proteingym: Large-scale benchmarks for protein design and fitness prediction
Predicting the effects of mutations in proteins is critical to many applications, from
understanding genetic disease to designing novel proteins that can address our most …
understanding genetic disease to designing novel proteins that can address our most …
Deep indel mutagenesis reveals the impact of amino acid insertions and deletions on protein stability and function
Amino acid insertions and deletions (indels) are an abundant class of genetic variants.
However, compared to substitutions, the effects of indels on protein stability are not well …
However, compared to substitutions, the effects of indels on protein stability are not well …
[HTML][HTML] Targeted mutagenesis of negatively charged amino acids outlining the substrate translocation path within the human organic cation transporter 3
KEM Redeker, S Schröder, C Dücker… - Biochemical …, 2024 - Elsevier
Recently published cryo-EM structures of human organic cation transporters of the SLC22
family revealed seven, sequentially arranged glutamic and aspartic acid residues, which …
family revealed seven, sequentially arranged glutamic and aspartic acid residues, which …
Large language models for biological prediction and design
A Kollasch - 2024 - dash.harvard.edu
Predicting the functional impact of changes to biological sequences is a central challenge in
genetics and biology. Beyond genetics, sequence-to-function mapping has key applications …
genetics and biology. Beyond genetics, sequence-to-function mapping has key applications …
[HTML][HTML] Molecular basis of proton-sensing by G protein-coupled receptors
Three proton-sensing G protein-coupled receptors (GPCRs), GPR4, GPR65, and GPR68,
respond to changes in extracellular pH to regulate diverse physiology and are implicated in …
respond to changes in extracellular pH to regulate diverse physiology and are implicated in …