Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities
The heat shock proteins (HSPs) are ubiquitous and conserved protein families in both
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
prokaryotic and eukaryotic organisms, and they maintain cellular proteostasis and protect …
Revisiting biomarker discovery by plasma proteomics
PE Geyer, LM Holdt, D Teupser… - Molecular systems biology, 2017 - embopress.org
Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and
blood biomarkers are used to categorize patients and to support treatment decisions …
blood biomarkers are used to categorize patients and to support treatment decisions …
Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation
Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …
disease biomarkers. However, certain critical steps of study design such as cohort selection …
Next-generation proteomics: towards an integrative view of proteome dynamics
Next-generation sequencing allows the analysis of genomes, including those representing
disease states. However, the causes of most disorders are multifactorial, and systems-level …
disease states. However, the causes of most disorders are multifactorial, and systems-level …
[HTML][HTML] Isolation of extracellular vesicles with combined enrichment methods
Extracellular vesicles (EVs) are currently of tremendous interest in many research
disciplines and EVs have potential for development of EV diagnostics or therapeutics. Most …
disciplines and EVs have potential for development of EV diagnostics or therapeutics. Most …
Plasma Proteome Profiling to detect and avoid sample‐related biases in biomarker studies
Plasma and serum are rich sources of information regarding an individual's health state, and
protein tests inform medical decision making. Despite major investments, few new …
protein tests inform medical decision making. Despite major investments, few new …
The role of heat shock proteins in cancer
Heat shock proteins (HSPs) are an evolutionary family of proteins that act as molecular
chaperones. According to their size they have been classified into the following families; …
chaperones. According to their size they have been classified into the following families; …
A random forest based biomarker discovery and power analysis framework for diagnostics research
Background Biomarker identification is one of the major and important goal of functional
genomics and translational medicine studies. Large scale–omics data are increasingly …
genomics and translational medicine studies. Large scale–omics data are increasingly …
The origin and activities of IgA1-containing immune complexes in IgA nephropathy
B Knoppova, C Reily, N Maillard, DV Rizk… - Frontiers in …, 2016 - frontiersin.org
IgA nephropathy (IgAN) is the most common primary glomerulonephritis, frequently leading
to end-stage renal disease, as there is no disease-specific therapy. IgAN is diagnosed from …
to end-stage renal disease, as there is no disease-specific therapy. IgAN is diagnosed from …
The case for proteomics and phospho‐proteomics in personalized cancer medicine
The concept of personalized medicine is predominantly been pursued through genomic and
transcriptomic technologies, leading to the identification of multiple mutations in a large …
transcriptomic technologies, leading to the identification of multiple mutations in a large …