Alterations in the chromatin packaging, driven by transcriptional activity, revealed by AFM

VY Bairamukov, RA Kovalev, AV Ankudinov… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Background The gene expression differs in the nuclei of normal and malignant mammalian
cells, and transcription is a critical initial step, which defines the difference. The mechanical …

Polymer Model Unveils Quantitative Association of Chromatin Conformation and Gene Regulation

S Senapati, I Shah, AK Sharma, H Kumar - bioRxiv, 2023 - biorxiv.org
The spatial organization of chromatin in the nucleus is of essence for regulating gene
transcription. However, the mechanisms governing the intricate interplay of chromatin …