▪ Abstract A life course approach to chronic disease epidemiology uses a multidisciplinary
framework to understand the importance of time and timing in associations between …

risk factors and lowered cardiovascular mortality slightly. 22 Interventions to control blood
cholesterol, blood pressure, and smoking for 7 years led to a 11.4% reduction in CHD …

ContextAtherosclerosis, the underlying cause of coronary heart disease, has been shown to
be present even in young adults. ObjectiveTo document the extent and severity of …

Obesity is a major contributor to the prevalence of cardiovascular disease in the developed
world, and yet has only recently been afforded the same level of attention as other risk …

The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study was organized
to document the natural history of atherosclerosis and to determine the relation of …

Atherosclerosis begins in childhood with the appearance of aortic fatty streaks. Aortic fatty
streaks of some degree are present in practically all individuals from every human …

Populations of industrialized countries are becoming more overweight as a result of
deleterious changes in lifestyle, and obesity is expected to become the most common health …

Publisher Summary This chapter discusses the relationship between plasma and tissue
lipids in human atherosclerosis. The concentration of lipoprotein in normal intima is highly …

The paper describes the general outline of a multicentre study on the risk factors of coronary
heart disease (CHD) and their determinants in children of various ages in different parts of …

This paper traces the development of knowledge concerning early lesions of atherosclerosis
and the relationship to risk factors in children, youth, and young adults. Autopsy studies have …