Cancer is one of the leading causes of death worldwide. There is a definite need for novel
approaches to improve the diagnostics and treatment of cancers. The pathological …

Genetic variation, which is generated by mutation, recombination and gene flow, can reduce
the mean fitness of a population, both now and in the future. This 'genetic load'has been …

Computational evolutionary biology, statistical phylogenetics and coalescent-based
population genetics are becoming increasingly central to the analysis and understanding of …

We present a new open source, extensible and flexible software platform for Bayesian
evolutionary analysis called BEAST 2. This software platform is a re-design of the popular …

Until recently, it has been common practice for a phylogenetic analysis to use a single gene
sequence from a single individual organism as a proxy for an entire species. With …

Species delimitation is the act of identifying species‐level biological diversity. In recent
years, the field has witnessed a dramatic increase in the number of methods available for …

Abstract Background Reconstructing phylogenies through Bayesian methods has many
benefits, which include providing a mathematically sound framework, providing realistic …

What are the models used in phylogenetic analysis and what exactly is involved in Bayesian
evolutionary analysis using Markov chain Monte Carlo (MCMC) methods? How can you …

For many biological investigations, groups of individuals are genetically sampled from
several geographic locations. These sampling locations often do not reflect the genetic …

The exact timing, route, and process of the initial peopling of the Americas remains uncertain
despite much research. Archaeological evidence indicates the presence of humans as far as …