Authors
Kok Wee Chong, Derrick WS Chan, Yin Bun Cheung, Leng Kee Ching, Szu Liang Hie, Terrence Thomas, Simon Ling, Ene Choo Tan
Publication date
2014/6/1
Journal
Archives of disease in childhood
Volume
99
Issue
6
Pages
581-584
Publisher
BMJ Publishing Group Ltd
Description
Objectives
To determine the association between severe cutaneous drug reactions (SCDR), HLA-B*1502 allelism, carbamazepine dose and treatment duration in a Singapore paediatric population.
Method
Case–control study of SCDR with carbamazepine and HLA-B*1502. We recruited 32 cases, 5 with Steven Johnson Syndrome/Toxic Epidermolytic Necrolysis (SJS/TEN) (2 Chinese, 3 Malay), 6 with hypersensitivity syndrome (HSS) (5 Chinese, 1 Indian), 11 with minor drug reactions (9 Chinese, 2 Malay) and 10 controls (7 Chinese, 2 Malay, 1 Indian). HLA-B*1502 allelism was assayed. HLA-B*1502 status and the type of drug reaction were compared using univariate analysis. The time-span from treatment onset to reaction and the dose-time to reaction association in the 3 groups were analysed.
Results
HLA-B*1502 was positive in: 5/5 (SJS/TEN), 0/6 (HSS), 1/11 (minor drug reactions) and 1/10 controls. OR for …
Scholar articles
KW Chong, DWS Chan, YB Cheung, LK Ching, SL Hie… - Archives of disease in childhood, 2014