Ester coupling reactions--an enduring challenge in the chemical synthesis of bioactive natural products

Nat Prod Rep. 2015 Apr;32(4):605-32. doi: 10.1039/c4np00106k.

Authors

Michail Tsakos¹, Eva S Schaffert, Lise L Clement, Nikolaj L Villadsen, Thomas B Poulsen

Affiliation

¹ Chemical Biology Laboratory, Department of Chemistry, Aarhus University, DK-8000, Aarhus C, Denmark. thpou@chem.au.dk.

PMID: 25572105
DOI: 10.1039/c4np00106k

Abstract

In this review we investigate the use of complex ester fragment couplings within natural product total synthesis campaigns. We first outline the different biosynthetic and chemical strategies for performing complex ester couplings and on this mechanistic background we then present and discuss a collection of successful examples from the literature.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biological Products* / chemistry
Biological Products* / metabolism
Biological Products* / pharmacology
Esters
Molecular Structure

Substances

Biological Products
Esters